Cystatin C and Its Role in Patients with Type 1 and Type 2 Diabetes Mellitus

Cystatin C and Its Role in Patients with Type 1 and Type 2 Diabetes Mellitus
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胱抑素 C 及其在 1 型和 2 型糖尿病患者中的作用

DOI:
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发表时间:
2015
期刊:
影响因子:
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通讯作者:
Fauzia Rashid
Fauzia Rashid
中科院分区:
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文献类型:
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作者:
A. Bashier;A. Fadlallah;A. Fadlallah;Nada Alhashemi;P. Thadani;E. Abdelgadir;Fauzia Rashid

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糖尿病是慢性肾脏病最常见的病因。它是需要肾脏替代疗法的新患者的主要原因,分别占美国、德国和澳大利亚病例的40%、34%和30%。最近的研究表明,一种被肾脏自由过滤的低分子蛋白--胱抑素C是一种新的生物标志物,可用于检测1型或2型糖尿病患者的早期肾功能障碍。胱抑素C还被证明可以检测糖尿病患者的心血管疾病,它也可能与肥胖患者发生2型糖尿病有关。我们的目标是回顾目前文献中使用胱抑素C与传统方法相比早期检测1型和2型糖尿病所致糖尿病肾病的证据,并探讨其与其他合并症的关系。
Diabetes mellitus is the commonest cause of CKD. It is the leading cause of new patients requiring renal replacement therapy, accounting for 40%, 34%, and 30% of cases in United States, Germany, and Australia, respectively. Recent studies have shown that a low-molecular weight protein, cystatin C, freely filtered by the kidneys is a novel biomarker that may be used for detection of early renal dysfunction in patients with type 1 or type 2 diabetes. Cystatin C has also been shown to detect cardiovascular disease in patients with diabetes and it may also be linked with incident type 2 diabetes in obese patients. We aim to review current evidence based literature on use of cystatin C for early detection of diabetic nephropathy due to type 1 and type 2 diabetes in comparison to conventional methods and explore its association with other comorbidities.
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