The vitamin D receptor gene BsmI polymorphism is not associated with anthropometric and biochemical parameters describing metabolic syndrome in postmenopausal women
The vitamin D receptor gene BsmI polymorphism is not associated with anthropometric and biochemical parameters describing metabolic syndrome in postmenopausal women
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DOI：
10.1080/09513590802302985
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发表时间：
2008-01-01
影响因子：
2
通讯作者：
Milewicz, Andrzej
中科院分区：
文献类型：
--
作者：
Tworowska-Bardzinska, Urszula;Lwow, Felicja;Milewicz, Andrzej
的目标。维生素D可能直接影响脂肪细胞的分化和代谢，并可能参与葡萄糖调节胰岛素分泌。近年来，研究人员发现了维生素D受体（VDR）编码基因的几种多态性，这些多态性可能会改变VDR蛋白的活性。本研究旨在探讨VDR BsmI多态性在绝经后妇女代谢综合征中的患病率及其与人体测量学和生化特征的关系。材料和方法。我们随机选取351名健康绝经后妇女，平均年龄55.43 +/- 2.75岁，平均体重指数（BMI）为27.5 +/- 4.78kg/m(2)，评估VDR基因中BsmI多态性（通过限制性片段长度多态性-聚合酶链反应）的频率，并探讨这种多态性与BMI、总脂肪体积和脏器脂肪（通过全身双能x线吸收仪测定）、血压、体重、体重、体重和体重之间是否存在关联。脂质谱（总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、甘油三酯）、葡萄糖和空腹胰岛素在整个组，以及肥胖和非肥胖妇女亚组中的变化。研究组BsmI基因型患病率分别为51.0% Bb、37.3% Bb和11.7% Bb。基因型分布与Hardy-Weinberg平衡条件下的预期没有差异（chi(2)=2.95, p=0.22）。除LDL-C水平（F=3.46, p=0.032）外，基因型间人体测量学和代谢参数均无显著差异。VDR基因的BsmI多态性似乎不会导致肥胖和胰岛素抵抗，但BB基因型与不利的脂质谱有关。
Aim. Vitamin D could have a direct effect on adipocyte differentiation and metabolism and might be involved in glucose regulation of insulin secretion. In recent years several polymorphisms in the gene encoding the vitamin D receptor (VDR), which are potent to alter the activity of VDR protein, have been described. The present study aimed to investigate the prevalence of the VDR BsmI polymorphism and its association with anthropometric and biochemical features of metabolic syndrome in postmenopausal women.Materials and methods. We studied 351 randomly selected healthy postmenopausal women, with mean age of 55.43 +/- 2.75 years and mean body mass index (BMI) of 27.5 +/- 4.78kg/m(2), to evaluate the frequency of BsmI polymorphism (by restriction fragment length polymorphism-polymerase chain reaction) in the VDR gene and to find out whether there is an association between this polymorphism and BMI, total fat volume and visceral fat (as determined by total body dual-energy X-ray absorptiometry), blood pressure, lipid profile (total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol, triglycerides) glucose and fasting insulin in the whole group, as well as subgroups of obese and non-obese women.Results. The prevalence of BsmI genotypes in the study group was 51.0% Bb, 37.3% bb and 11.7% BB. Genotype distribution did not differ from that expected under Hardy-Weinberg equilibrium conditions (chi(2)=2.95, p=0.22). Apart from LDL-C levels (F=3.46, p=0.032), there were no significant differences in anthropometric or metabolic parameters between genotypes.Conclusions. The BsmI polymorphism in the VDR gene does not seem to predispose to obesity and insulin resistance, but the BB genotype is connected with an unfavorable lipid profile.