Range-of-motion affects cartilage fluid load support: functional implications for prolonged inactivity
Range-of-motion affects cartilage fluid load support: functional implications for prolonged inactivity
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DOI：
10.1016/j.joca.2020.11.005
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发表时间：
2021-01-01
影响因子：
7
通讯作者：
Burris, D. L.
中科院分区：
文献类型：
--
作者：
Benson, J. M.;Kook, C.;Burris, D. L.
目的：关节活动通过接触迁移和周期性沐浴暴露相结合的方式维持软骨液体负荷支持(FLS)。尽管有人提出，在长时间不活动期间，微小的不自主运动可能会扰乱负荷诱导的渗出，但理论研究表明并非如此。本研究使用可控外植体测量方法对现有的假说进行实验验证，该假说认为运动范围必须超过接触长度才能维持非零的FL。方法：使用定制的仪器在不同的法向载荷(0.05-0.1N)和迁移长度(0.05-7 mm)下，以1.5 mm/S(Peclet数)的速度滑动光滑的玻璃球(半径1.2-3.2 mm)。结果：在0.0 5 mm或0.0 5 mm的迁移长度范围内，FLS均保持非零值。
Objective: Joint movements sustain cartilage fluid load support (FLS) through a combination of contact migration and periodic bath exposure. Although there have been suggestions that small involuntary movements may disrupt load-induced exudation during prolonged inactivity, theoretical studies have shown otherwise. This work used well-controlled explant measurements to experimentally test an existing hypothesis that the range-of-motion must exceed the contact length to sustain non-zero FLS.Method: Smooth glass spheres (1.2-3.2 mm radius) were slid at 1.5 mm/s (Peclet number >100) against bovine osteochondral explants under varying normal loads (0.05-0.1 N) and migration lengths (0.05 -7 mm) using a custom instrument. In situ deformation measurements were used to quantify FLS.Results: Non-zero FLS was maintained at migration lengths as small as 0.05 mm or