DIZOCILPINE ANTAGONIZES THE EFFECT OF CHRONIC IMIPRAMINE ON LEARNED HELPLESSNESS IN RATS
DIZOCILPINE ANTAGONIZES THE EFFECT OF CHRONIC IMIPRAMINE ON LEARNED HELPLESSNESS IN RATS
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DOI：
10.1016/0091-3057(93)90374-3
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发表时间：
1993-10-01
影响因子：
3.6
通讯作者：
TAGLIAMONTE, A
中科院分区：
文献类型：
--
作者：
MELONI, D;GAMBARANA, C;TAGLIAMONTE, A
通过植入 SC 的微型渗透泵将地佐西平与丙咪嗪 (IMI) 联合给药，可完全防止喹吡罗行为超敏反应的发生，以及多巴胺 D-1 和 P-肾上腺素能受体功能的降低。本报告表明，在相同的实验条件下，地佐环平完全拮抗IMI阻止大鼠习得性无助行为发展的能力。由此表明，NMDA 受体的阻断也会拮抗 IMI 的抗抑郁作用。有趣的是，在不可避免的电击过程前 30 分钟用地佐西平急性治疗的大鼠在逃脱测试过程中的表现与幼稚动物相似。
Dizocilpine coadministered with imipramine (IMI) through an SC-implanted osmotic minipump completely prevents the occurrence of behavioral supersensitivity to quinpirole, as well as the decrease of dopamine D-1 and P-adrenergic receptor function. The present report shows that, in the same experimental conditions, dizocilpine completely antagonized the capacity of IMI to prevent the development of the learned helplessness behavior in rats. Thus suggesting that the blockade of NMDA receptors also antagonizes the antidepressant effect of IMI. Interestingly, rats acutely treated with dizocilpine 30 min before the inescapable shock session behaved similarly to naive animals during the escape test session.