The Relationship between ALA16VAL Single Gene Polymorphism and Renal Cell Carcinoma.
The Relationship between ALA16VAL Single Gene Polymorphism and Renal Cell Carcinoma.
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DOI：
10.1155/2014/932481
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发表时间：
2014
影响因子：
1.4
通讯作者：
Erkorkmaz U
中科院分区：
文献类型：
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作者：
Atilgan D;Parlaktas BS;Uluocak N;Kolukcu E;Erdemir F;Ozyurt H;Erkorkmaz U
目标.本研究的目的是探讨土耳其RCC患者中RCC和Ala16Val多态性的相关性。材料和方法。本研究共纳入41例肾细胞癌患者和50例健康志愿者，他们在我们的诊所接受了根治性或部分肾切除术，生活在同一地理区域。从RCC患者和对照血清DNA样品进行MnSOD多态性分析的基因型。比较两组基因型比例和等位基因频率，并计算比值比和95%可信区间。P值<0.05被认为具有统计学显著性。结果MnSOD基因型在肾癌组和对照组中的分布差异有统计学意义（P = 0.039），其中Ala/Ala + Ala/瓦尔和瓦尔/瓦尔基因型分布差异有统计学意义（P = 0.039）。Ala/Ala + Ala/瓦尔基因型与肾细胞癌的危险度为2.64（95%CI = 1.06-6.69，P = 0.039）。此外，Ala等位基因与肾细胞癌的危险性显著相关，OR值为2.26（95% CI = 1.24-4.12，P = 0.009）。结论我们的研究表明，MnSOD Ala16Val多态性可能是土耳其患者肾癌易感性的遗传因素之一。
Objectives. The aim of this study was to investigate the association of RCC and Ala16Val polymorphism in Turkish patients with RCC. Materials and Methods. A total of 41 patients with RCC who underwent radical or partial nephrectomy in our clinic and 50 healthy volunteers living in the same geographic area were included in this study. DNA samples from serum of RCC patients and controls were genotyped for MnSOD polymorphism analysis. Genotype ratios and allele frequencies were compared between two groups and odd ratios with 95% confidence intervals were calculated statistically. A P value of <0.05 was considered statistically significant. Results. There was a significant difference in the MnSOD genotype distributions between the RCC patients and the controls in terms of Ala/Ala+Ala/Val and Val/Val genotypes (P = 0.039). The Ala/Ala+Ala/Val genotypes were found significantly suspicious for RCC with an OR of 2.64 (95% CI = 1.06–6.69, P = 0.039). In addition, Ala allele was found significantly suspicious for RCC with an OR of 2.26 (95% CI = 1.24–4.12, P = 0.009). Conclusion. Our study indicated that MnSOD Ala16Val polymorphism may be one of the many genetic factors for renal cancer susceptibility in Turkish patients.