Developing an international network for Alzheimer research: The Dominantly Inherited Alzheimer Network.
Developing an international network for Alzheimer research: The Dominantly Inherited Alzheimer Network.
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DOI：
10.4155/cli.12.93
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发表时间：
2012-10-01
期刊：
影响因子：
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通讯作者：
Buckles VD
中科院分区：
文献类型：
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作者：
Morris JC;Aisen PS;Bateman RJ;Benzinger TL;Cairns NJ;Fagan AM;Ghetti B;Goate AM;Holtzman DM;Klunk WE;McDade E;Marcus DS;Martins RN;Masters CL;Mayeux R;Oliver A;Quaid K;Ringman JM;Rossor MN;Salloway S;Schofield PR;Selsor NJ;Sperling RA;Weiner MW;Xiong C;Moulder KL;Buckles VD
显性遗传阿尔茨海默病网络（DIAN）是国际阿尔茨海默病（AD）中心的合作努力，正在对常染色体显性AD（ADAD）风险个体进行多方面的前瞻性生物标志物研究。DIAN根据标准方案从无症状和有症状的ADAD突变携带者及其非携带者家族成员中收集全面的信息和组织，以确定AD的临床、认知、神经影像学和液体生物标志物的病理年代学。本文描述了DIAN的结构、实施和基本原则，以及初始DIAN队列的人口统计学特征。
The Dominantly Inherited Alzheimer Network (DIAN) is a collaborative effort of international Alzheimer disease (AD) centers that are conducting a multifaceted prospective biomarker study in individuals at-risk for autosomal dominant AD (ADAD). DIAN collects comprehensive information and tissue in accordance with standard protocols from asymptomatic and symptomatic ADAD mutation carriers and their non-carrier family members to determine the pathochronology of clinical, cognitive, neuroimaging, and fluid biomarkers of AD. This article describes the structure, implementation, and underlying principles of DIAN, as well as the demographic features of the initial DIAN cohort.