Synapse-associated protein 90/postsynaptic density-95-associated protein (SAPAP) is expressed differentially in phencyclidine-treated rats and is increased in the nucleus accumbens of patients with schizophrenia
Synapse-associated protein 90/postsynaptic density-95-associated protein (SAPAP) is expressed differentially in phencyclidine-treated rats and is increased in the nucleus accumbens of patients with schizophrenia
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DOI：
10.1038/sj.npp.1300212
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发表时间：
2003-10-01
影响因子：
7.6
通讯作者：
Maeda, K
中科院分区：
文献类型：
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作者：
Kajimoto, Y;Shirakawa, O;Maeda, K
苯环利定（PCP）诱导一种类似精神分裂症的拟精神病状态。因此，PCP处理的动物可以提供精神分裂症的模型。利用差异显示技术，我们在大鼠延髓核（NAcs）中发现了一个受PCP延迟作用调控的基因。序列分析表明，获得的cDNA克隆是相同的大鼠突触相关蛋白90/突触后密度-95相关蛋白1（SAPAP 1）。RT-PCR定量分析显示，大鼠NAc中SAPAP 1 mRNA表达明显增加（P
Phencyclidine (PCP) induces a psychotomimetic state that closely resembles schizophrenia. Therefore, PCP-treated animals can provide a model for schizophrenia. Using differential display, we identified a gene regulated by the delayed action of PCP in rat nucleus accumbens (NAcs). Sequence analysis showed that the cDNA clone obtained was identical to rat synapse-associated protein 90/ postsynaptic density-95-associated protein 1 (SAPAP1). Quantitative reverse transcriptase (RT)-PCR analysis showed that SAPAP1 mRNA had increased significantly in rat NAc (P