Molecular epidemiology of hepatitis B and C virus infections in Asia
Molecular epidemiology of hepatitis B and C virus infections in Asia
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DOI：
10.1046/j.1442-200x.2004.01867.x
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发表时间：
2004-04-01
影响因子：
1.4
通讯作者：
Abe, K
中科院分区：
文献类型：
--
作者：
Huy, TTT;Abe, K
本文综述了目前关于B型肝炎病毒（HBV）和丙型肝炎病毒（HCV）的分子流行病学文献，这两种病毒是世界范围内血源性传染病的重要病原体。特别是，HBV和HCV在亚洲大陆广泛分布，并与急性和慢性肝病相关，包括肝细胞癌。HBV已被分为基因型A至G，并显示具有不同的地理分布。在亚洲，HBV基因型B和C占优势，基因型C已被证明比基因型B引起更严重的肝病。亚洲地区HBV变异株的流行率较高，如前S区变异株、基本核心启动子变异株、YMDD基序变异株和疫苗逃逸变异株，这些变异株与肝病的严重程度和治疗敏感性有关。HCV也被分为多种基因型，并与地理分布有关。HCV基因型1对干扰素治疗的敏感性较低，并且可能与比其他基因型更严重的肝脏疾病的存在相关。数据之间的关系HBV/HCV基因型，其致病性在慢性肝病，包括肝细胞癌和治疗的影响，等待着极大的兴趣，特别是在亚洲，这是一个地方性地区的血源性肝炎病毒。
The present paper provides a review of the current literature regarding the molecular-based epidemiology of hepatitis B virus (HBV) and hepatitis C virus (HCV), which are very important viruses underlying the etiology of blood-borne infectious diseases worldwide. Particularly, both HBV and HCV are widespread on the Asian continent and are associated with acute and chronic liver diseases, including hepatocellular carcinoma. HBV has been classified into genotypes A through G and shown to have a distinct geographic distribution. In Asia, genotypes B and C of HBV prevail, and genotype C has been shown to cause more serious liver disease than genotype B. High prevalence of HBV mutants with various forms, such as the pre-S mutant, basal core promoter mutant, YMDD motif mutant and vaccine escape mutant, were seen in Asia and these were found to be related to the severity of liver disease and sensitivity to therapy. HCV has also been classified into multiple genotypes and associated with geographic distribution. HCV genotype 1 is less sensitive to interferon therapy and may be associated with the presence of more serious liver disease than the other genotypes. Data on the relation among the HBV/HCV genotypes, their pathogenicity in chronic liver diseases including hepatocellular carcinoma and their effect on therapy are awaited with great interest, especially in Asia, which is an endemic region of blood-borne hepatitis viruses.