Partitioning of inhaled ventilation between the nasal and oral routes during sleep in normal subjects
Partitioning of inhaled ventilation between the nasal and oral routes during sleep in normal subjects
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DOI：
10.1152/japplphysiol.00658.2002
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发表时间：
2003-03-01
影响因子：
3.3
通讯作者：
Girard, AM
中科院分区：
文献类型：
--
作者：
Fitzpatrick, MF;Driver, HS;Girard, AM
10名年龄43+/-5岁、鼻阻力正常(平均2.0+/-0.3cmH(2)O.L(-1).s(-1))的健康受试者(男5人，女5人)在睡眠中同时量化口腔和鼻腔对吸入性通气量的贡献。清醒时每分钟通气量(5.9±-0.3)L/分钟高于睡眠时(5.2±-0.3)L/分钟(P<；0.0001)，但不同睡眠阶段(2 5.3+/-0.3、慢波5.2+/-0.2、快眼动睡眠5.2+/-0.2 L/分钟)的每分钟通气量无显著差异(P=0.44)。清醒时口腔吸气分数(7.6±-4%)与睡眠时口腔分数(4.3±2%)差异无统计学意义(P=0.19)，平均差异3.3%，95%可信区间-2.1~8.8%，P=0.19；不同睡眠阶段口腔分数差异无统计学意义(P=0.14)：阶段2 5.1±-2.8，慢波4.2+/-1.8，快眼动3.1+/-1.7%。因此，正常受试者的吸入性口腔分数很小，且不随睡眠阶段的变化而明显变化。
The oral and nasal contributions to inhaled ventilation were simultaneously quantified during sleep in 10 healthy subjects (5 men, 5 women) aged 43 +/- 5 yr, with normal nasal resistance (mean 2.0 +/- 0.3 cmH(2)O.l(-1).s(-1)) by use of a divided oral and nasal mask. Minute ventilation awake (5.9 +/- 0.3 l/min) was higher than that during sleep (5.2 +/- 0.3 l/min; P < 0.0001), but there was no significant difference in minute ventilation between different sleep stages (P = 0.44): stage 25.3 +/- 0.3, slow-wave 5.2 +/- 0.2, and rapid-eye-movement sleep 5.2 +/- 0.2 l/min. The oral fraction of inhaled ventilation during wakefulness (7.6 +/- 4%) was not significantly different from that during sleep (4.3 +/- 2%; mean difference 3.3%, 95% confidence interval -2.1-8.8%, P = 0.19), and no significant difference (P = 0.14) in oral fraction was observed between different sleep stages: stage two 5.1 +/- 2.8, slow-wave 4.2 +/- 1.8, rapid-eye-movement 3.1 +/- 1.7%. Thus the inhaled oral fraction in normal subjects is small and does not change significantly with sleep stage.