Impact of in-scanner head motion on multiple measures of functional connectivity: relevance for studies of neurodevelopment in youth.
Impact of in-scanner head motion on multiple measures of functional connectivity: relevance for studies of neurodevelopment in youth.
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DOI：
10.1016/j.neuroimage.2011.12.063
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发表时间：
2012-03
期刊：
影响因子：
5.7
通讯作者：
Gur, Raquel E.
中科院分区：
文献类型：
--
作者：
Satterthwaite, Theodore D.;Wolf, Daniel H.;Loughead, James;Ruparel, Kosha;Elliott, Mark A.;Hakonarson, Hakon;Gur, Ruben C.;Gur, Raquel E.
最近有报道称，在扫描仪内的头部运动可以对静息状态功能连接的MRI测量产生实质性影响。这一发现可能与青少年神经发育的研究特别相关，混淆了运动和受试者年龄相关的分析。此外，虽然Van Dijk等人证明了运动对基于种子的连通性分析的影响，但尚不清楚运动如何影响其他常见的连通性测量。在这里，我们扩展了Van Dijk等人的发现，通过检查运动对儿童和青少年（n=456）多种静息状态连通性分析的影响。在复制了运动对基于种子的分析的影响之后，我们研究了运动对网络模块化的图形测量、独立分量分析的双回归以及低频波动的幅度和分数幅度的影响。在整个样本中，受试者的年龄与运动高度相关。使用年龄和运动不相关的子样本，我们证明运动在每个分析中都对连通性有显著影响。虽然被试的年龄与网络内连接的增加有关，即使运动被考虑在内，但控制运动大大减弱了这种关系的强度。结果表明运动对多种类型的功能连接分析的普遍影响，并强调了运动在神经发育研究中的重要性。
It has recently been reported that in-scanner head motion can have a substantial impact on MRI measurements of resting-state functional connectivity. This finding may be of particular relevance for studies of neurodevelopment in youth, confounding analyses to the extent that motion and subject age are related. Furthermore, while Van Dijk et al. demonstrated the effect of motion on seed-based connectivity analyses, it is not known how motion impacts other common measures of connectivity. Here we expand on the findings of Van Dijk et al. by examining the effect of motion on multiple types of resting-state connectivity analyses in a large sample of children and adolescents (n=456). Following replication of the effect of motion on seed-based analyses, we examine the influence of motion on graphical measures of network modularity, dual-regression of independent component analysis, as well as the amplitude and fractional amplitude of low frequency fluctuation. In the entire sample, subject age was highly related to motion. Using a subsample where age and motion were unrelated, we demonstrate that motion has marked effects on connectivity in every analysis examined. While subject age was associated with increased within-network connectivity even when motion was accounted for, controlling for motion substantially attenuated the strength of this relationship. The results demonstrate the pervasive influence of motion on multiple types functional connectivity analysis, and underline the importance of accounting for motion in studies of neurodevelopment.
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DOI：
10.1523/jneurosci.1929-08.2008
发表时间：
2008-09-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bassett DS;Bullmore E;Verchinski BA;Mattay VS;Weinberger DR;Meyer-Lindenberg A
通讯作者：
Meyer-Lindenberg A
影响因子：
5.3
作者：
Achard, S;Salvador, R;Bullmore, ET
通讯作者：
Bullmore, ET
影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
Beckmann, CF;DeLuca, M;Smith, SM
通讯作者：
Smith, SM
影响因子：
3.3
作者：
Liao, Rui;McKeown, Martin J.;Krolik, Jeffrey L.
通讯作者：
Krolik, Jeffrey L.