Adiponectin complexes composition in Japanese-Brazilians regarding their glucose tolerance status
Adiponectin complexes composition in Japanese-Brazilians regarding their glucose tolerance status
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DOI：
10.1186/1758-5996-5-20
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发表时间：
2013-04-09
影响因子：
4.8
通讯作者：
Moises, Regina S.
中科院分区：
文献类型：
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作者：
Crispim, Felipe;Vendramini, Marcio F.;Moises, Regina S.
背景：脂联素存在于不同的多聚体复合体中，包括低分子三聚体(LMW)、中分子六聚体(MMW)和高分子多聚体(HMW)。方法：对26例糖尿病患者(DM，女性14例，男性12例，年龄55.3±8.6岁)和年龄匹配的正常糖耐量对照组27例(NGT，女性12例，男性15例，年龄54.0±9.2岁)进行检测。结果：两组患者血清总脂联素水平差异无统计学意义(NGT：6.90ug/ml(4.38-13.43)；DM：5.38 ug/ml(3.76-8.56)，P=0.35；MMW[NGT：2.34 ug/ml(1.38-3.25)；DM：1.80 ug/ml(1.18-2.84)，p=0.48]或LMW脂联素[NGT：2.07 ug/ml(1.45-3.48)，DM：2.93 ug/ml(1.78-3.99)，p=0.32]。相比之下，糖尿病患者高分子脂联素水平显著降低[TGN：2.39ug/ml(1.2~4.75)；DM：1.04ug/ml(0.42~1.60)，P=0.001]。进行Logistic回归分析以确定与糖尿病的独立关联。结果表明，女性的HOMA-IR和HMW脂联素与糖尿病独立相关。结论：目前的研究表明，在日裔巴西人中，2型糖尿病患者的HMW脂联素选择性降低，而在MMW和LMW脂联素亚型中没有发现差异。
Background: Adiponectin circulates in different multimer complexes comprised of low molecular weight trimeric form (LMW), hexamer of middle molecular weight (MMW) and high molecular weight multimers (HMW). In Japanese-Brazilians, a population with high prevalence of glucose metabolism disturbances, we examined the associations of total adiponectin and its multimers with diabetes mellitus.Methods: Two study groups were examined: 26 patients with diabetes mellitus (DM, 14 women and 12 men, aged 55.3 +/- 8.6 years) and 27 age-matched control subjects with normal glucose tolerance (NGT, 12 women and 15 men, aged 54.0 +/- 9.2 years).Results: We found no significant differences in total [NGT: 6.90 ug/ml (4.38-13.43); DM: 5.38 ug/ml (3.76-8.56), p = 0.35], MMW [NGT: 2.34 ug/ml (1.38-3.25); DM: 1.80 ug/ml (1.18-2.84), p = 0.48] or LMW adiponectin [NGT: 2.07 ug/ml (1.45-3.48), DM: 2.93 ug/ml (1.78-3.99), p = 0.32] between groups. In contrast, HMW adiponectin levels were significantly lower in patients with DM [TGN: 2.39 ug/ml (1.20-4.75); DM: 1.04 ug/ml (0.42-1.60), p = 0.001]. A logistic regression analysis was done to identify independent associations with diabetes mellitus. The results showed that HOMA-IR and HMW adiponectin in women were independently associated with diabetes mellitus.Conclusion: The current investigation demonstrates that in Japanese-Brazilians HMW adiponectin is selectively reduced in individuals with type 2 diabetes, while no differences were found in MMW and LMW adiponectin isoforms.