In utero exposure to selective serotonin re-uptake inhibitor affects murine mandibular development.
In utero exposure to selective serotonin re-uptake inhibitor affects murine mandibular development.
复制标题
在子宫内暴露于选择性血清素再摄取抑制剂会影响小鼠下颌发育。
DOI：
10.1111/ocr.12624
复制
发表时间：
2023
影响因子：
3.1
通讯作者：
Cray,JamesJ
中科院分区：
文献类型：
--
作者：
Boyce,MarkA;Durham,EmilyL;Kuo,Sharon;Taylor,JaneM;Kishinchand,Rajiv;LaRue,AmandaC;Cray,JamesJ
ObjectivesAntidepressants, specifically Selective Serotonin Re‐uptake Inhibitors (SSRIs), that alter serotonin metabolism are currently the most commonly prescribed drugs for the treatment of depression. There is some evidence to suggest these drugs contribute to birth defects. As jaw development is often altered in craniofacial birth defects, the purpose of this study was to interrogate the effects of in utero SSRI exposure in a preclinical model of mandible development.Materials and MethodsWild‐type C57BL6 mice were used to produce litters that were exposed in utero to an SSRI, Citalopram (500 μg/day). Murine mandibles from P15 pups were analysed for a change in shape and composition.ResultsAnalysis indicated an overall shape change with total mandibular length and ramus height being shorter in exposed pups as compared to controls. Histomorphometric analysis revealed that first molar length was longer in exposed pups while third molar length was shorter in exposed as compared to control. Histological investigation of molars and surrounding periodontium revealed no change in collagen content of the molar in exposed pups, some alteration in collagen composition in the periodontium, increased alkaline phosphatase in molars and periodontium and decreased mesenchymal cell marker presence in exposed mandibles.ConclusionThe results of this study reveal SSRI exposure may interrupt mandible growth as well as overall dental maturation in a model of development giving insight into the expectation that children exposed to SSRIs may require orthodontic intervention.
