Exercise training in hypertension: Role of microRNAs
Exercise training in hypertension: Role of microRNAs
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DOI：
10.4330/wjc.v6.i8.713
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发表时间：
2014-08-26
影响因子：
1.9
通讯作者：
de Oliveira, Edilamar Menezes
中科院分区：
文献类型：
--
作者：
das Neves, Vander Jose;Fernandes, Tiago;de Oliveira, Edilamar Menezes
高血压是一种复杂的疾病，是一个重要的公共卫生问题，需要进行大量的研究以了解其病理生理的分子机制。因此，进行了越来越多的研究，并不断发现新的治疗方法。在这种背景下，运动训练已经成为治疗高血压患者的一种重要的非药物治疗方法，它可以最大限度地减少药物治疗的副作用，并经常有助于暂停药物治疗。一些机制与高血压的发病机制有关，如交感神经系统和肾素-血管紧张素醛固酮系统的亢进，内皮一氧化氮生成受损，氧反应物质增加，血管增厚和硬化，心脏肥厚，血管生成受损，有时还有遗传易感性。随着microRNAs （miRNAs）的出现，人们对这种疾病的治疗有了新的认识，运动训练已被证明能够调节与之相关的miRNAs。阐明运动训练与mirna在高血压发病机制中的关系是了解运动如何在遗传水平上调节心血管系统的基础。即使对于新药的开发，这也是有希望的。本文综述了运动训练如何通过心脏、血管系统和骨骼肌中的特定mirna对高血压的作用。（三）2014年百世登出版集团股份有限公司版权所有。
Hypertension is a complex disease that constitutes an important public health problem and demands many studies in order to understand the molecular mechanisms involving his pathophysiology. Therefore, an increasing number of studies have been conducted and new therapies are continually being discovered. In this context, exercise training has emerged as an important non-pharmacological therapy to treat hypertensive patients, minimizing the side effects of pharmacological therapies and frequently contributing to allow pharmacotherapy to be suspended. Several mechanisms have been associated with the pathogenesis of hypertension, such as hyperactivity of the sympathetic nervous system and renin-angiotensin aldosterone system, impaired endothelial nitric oxide production, increased oxygen-reactive species, vascular thickening and stiffening, cardiac hypertrophy, impaired angiogenesis, and sometimes genetic predisposition. With the advent of microRNAs (miRNAs), new insights have been added to the perspectives for the treatment of this disease, and exercise training has been shown to be able to modulate the miRNAs associated with it. Elucidation of the relationship between exercise training and miRNAs in the pathogenesis of hypertension is fundamental in order to understand how exercise modulates the cardiovascular system at genetic level. This can be promising even for the development of new drugs. This article is a review of how exercise training acts on hypertension by means of specific miRNAs in the heart, vascular system, and skeletal muscle. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.