Excess cause-specific mortality in in-patient-treated individuals with personality disorder: 25-year nationwide population-based study
Excess cause-specific mortality in in-patient-treated individuals with personality disorder: 25-year nationwide population-based study
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DOI：
10.1192/bjp.bp.114.149583
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发表时间：
2015-10-01
影响因子：
10.5
通讯作者：
Ekselius, Lisa
中科院分区：
文献类型：
--
作者：
Bjorkenstam, Emma;Bjorkenstam, Charlotte;Ekselius, Lisa
背景虽然人格障碍与总体死亡率增加有关，但对死亡原因和人格类型知之甚少。目的是确定 ICD 人格障碍的死亡原因。方法基于瑞典全国登记册的数据，对 1987 年至 2011 年间因人格障碍初步诊断而入院的个体的死亡率进行随访，直至 2011 年 12 月 31 日。对具有 95% 置信区间的标准化死亡率 (SMR) 和潜在死亡原因进行了研究计算结果：自然死因和非自然死因的全因 SMR 总体上和所有集群中均有所增加。女性总体 SMR 为 6.1，男性为 5.0，与之前报道的神经性厌食症一样高，B 类和混合/其他人格障碍的比例更高。 B 类疾病的自杀 SMR 为 34.5，女性为 34.5，男性为 16.0。躯体和精神共病增加了 SMR。结论 所有人格障碍群的 SMR 均大幅增加。因此，无论类别如何，所有人格障碍的过早死亡风险都会增加。
BackgroundAlthough personality disorders are associated with increased overall mortality, less is known about cause of death and personality type.AimsTo determine causes of mortality in ICD personality disorders.MethodBased on data from Swedish nationwide registers, individuals admitted to hospital with a primary diagnosis of personality disorder between 1987 and 2011 were followed with respect to mortality until 31 December 2011. Standardised mortality ratios (SMRs) with 95% confidence intervals and underlying causes of death were calculated.ResultsAll-cause SMRs were increased, overall and in all clusters, for natural as well as unnatural causes of death. The overall SMR was 6.1 in women and 5.0 in men, as high as previously reported for anorexia nervosa, with higher rates in cluster B and mixed/other personality disorders. The SMR for suicide was 34.5 in women and 16.0 in men for cluster B disorders. Somatic and psychiatric comorbidity increased SMRs.ConclusionsThe SMR was substantially increased for all personality disorder clusters. Thus, there was an increased premature mortality risk for all personality disorders, irrespective of category.