Bright Air, Brilliant Fire: On the Matter of the Mind, Gerald M. Edelman. 1992. Basic Books, New York, NY. 280 pages. ISBN: 0-465-05245-2. $25.00
Bright Air, Brilliant Fire: On the Matter of the Mind, Gerald M. Edelman. 1992. Basic Books, New York, NY. 280 pages. ISBN: 0-465-05245-2. $25.00
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明亮的空气，灿烂的火焰：关于心灵的问题，杰拉尔德·M·埃德尔曼。
DOI：
10.1001/jama.1992.03490170112044
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发表时间：
1992
影响因子：
--
通讯作者：
G. Tremblay
中科院分区：
文献类型：
--
作者：
G. Tremblay
大脑就像免疫系统。两者都认识到外部影响并对它们作出反应。一种记忆存在于大脑和免疫细胞中。大脑和免疫系统之间的类比一直是杰拉尔德埃德尔曼的著作约20年的主题。除了他最近在神经科学方面的作品外，作者最出名的可能是破译抗体分子的结构。这项工作导致了1972年的诺贝尔奖。埃德尔曼还为我们理解细胞粘附分子做出了重要贡献，特别是那些指导大脑发育的分子。免疫系统针对无限多样的抗原产生特异性抗体。与预期相反，免疫细胞不会重新设计特异性抗体来适应抗原的形状。相反，已经携带合适抗体的预先存在的克隆通过它们与抗原的结合而被“选择”。选择的克隆增殖。未来风险
The brain is like the immune system. Both recognize external influences and respond to them. A type of memory is present in both brain and immune cells. The analogies between the brain and the immune system have been a topic of Gerald Edelman's writings for about 20 years. Apart from his more recent works in neuroscience, the author is probably best known for deciphering the structure of the antibody molecule. That work resulted in a Nobel Prize in 1972. Edelman has also made important contributions to our understanding of cell adhesion molecules, especially those that guide brain development. The immune system makes specific antibodies to an infinite diversity of antigens. Contrary to expectation, the immune cells do not design de novo specific antibodies to fit the antigen's shape. Instead, preexisting clones, which already bear suitable antibodies, are "selected" by their binding to the antigen. The selected clones proliferate. Future exposures