Chronic inflammation in the etiology of disease across the life span
Chronic inflammation in the etiology of disease across the life span
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DOI：
10.1038/s41591-019-0675-0
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发表时间：
2019-12-01
期刊：
影响因子：
82.9
通讯作者：
Slavich, George M.
中科院分区：
文献类型：
--
作者：
Furman, David;Campisi, Judith;Slavich, George M.
尽管炎症的间歇性增加对于身体受伤和感染期间的生存至关重要，但最近的研究表明，某些社会、环境和生活方式因素可以促进全身性慢性炎症 (SCI)，进而导致多种疾病，这些疾病共同代表了全世界残疾和死亡的主要原因，例如心血管疾病、癌症、糖尿病、慢性肾病、非酒精性脂肪肝 以及自身免疫性疾病和神经退行性疾病。在本视角中，我们描述了 SCI 的多层次机制以及促进这种损害健康表型的几个危险因素，包括感染、缺乏身体活动、不良饮食、环境和工业毒物以及心理压力。此外，我们还提出了推进 SCI 早期诊断、预防和治疗的潜在策略。
Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain social, environmental and lifestyle factors can promote systemic chronic inflammation (SCI) that can, in turn, lead to several diseases that collectively represent the leading causes of disability and mortality worldwide, such as cardiovascular disease, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease and autoimmune and neurodegenerative disorders. In the present Perspective we describe the multi-level mechanisms underlying SCI and several risk factors that promote this health-damaging phenotype, including infections, physical inactivity, poor diet, environmental and industrial toxicants and psychological stress. Furthermore, we suggest potential strategies for advancing the early diagnosis, prevention and treatment of SCI.