RAPAMYCIN GRAFT PRETREATMENT IN SMALL-BOWEL AND KIDNEY-TRANSPLANTATION IN THE RAT
RAPAMYCIN GRAFT PRETREATMENT IN SMALL-BOWEL AND KIDNEY-TRANSPLANTATION IN THE RAT
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DOI：
10.1097/00007890-199504270-00002
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发表时间：
1995-04-27
期刊：
影响因子：
6.2
通讯作者：
DALOZE, P
中科院分区：
文献类型：
--
作者：
CHEN, HF;XU, DS;DALOZE, P
在大鼠同种异体小肠和肾移植（Tx）中评价雷帕霉素（RAPA）作为移植物预处理的效果。在小肠Tx模型中，涉及六个组，每个组包括用于评价宿主抗移植物（HVG）[刘易斯（LEW）x Brown Norway（BN）（LBN）-F-1 ->刘易斯]、移植物抗宿主（GVH）（LEW --> F-1）和组合的HVG和GVH免疫应答（BN --> LEW）的三种组合。与对照组相比，RAPA移植物单独预处理（16 μ g/ml × 3 ml）能够在所有三种联合模型中诱导适度但显著的存活延长（P
The effect of rapamycin (RAPA) as graft pretreatment was evaluated in orthotopic small bowel and kidney allotransplantation (Tx) in the rat. In the small bowel Tx model, six groups were involved, each including three combinations for evaluation of host-versus-graft (HVG) [Lewis (LEW) x Brown Norway (BN) (LBN)-F-1 --> Lewis], graft-versus-host (GVH) (LEW --> F-1), and combined HVG and GVH immune responses (BN --> LEW). RAPA graft pretreatment alone (16 mu g/ml x 3 ml) was able to induce a modest but significant prolongation of survival in all three combination models compared with controls (P