The IMPACT framework and implementation for accessible in silico clinical phenotyping in the digital era.

The IMPACT framework and implementation for accessible in silico clinical phenotyping in the digital era.
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DOI:
10.1038/s41746-023-00878-9
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发表时间:
2023-07-21
影响因子:
15.2
通讯作者:
--
中科院分区:
医学1区
文献类型:
--
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Clinical phenotyping is often a foundational requirement for obtaining datasets necessary for the development of digital health applications. Traditionally done via manual abstraction, this task is often a bottleneck in development due to time and cost requirements, therefore raising significant interest in accomplishing this task via in-silico means. Nevertheless, current in-silico phenotyping development tends to be focused on a single phenotyping task resulting in a dearth of reusable tools supporting cross-task generalizable in-silico phenotyping. In addition, in-silico phenotyping remains largely inaccessible for a substantial portion of potentially interested users. Here, we highlight the barriers to the usage of in-silico phenotyping and potential solutions in the form of a framework of several desiderata as observed during our implementation of such tasks. In addition, we introduce an example implementation of said framework as a software application, with a focus on ease of adoption, cross-task reusability, and facilitating the clinical phenotyping algorithm development process.
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