The ion channels coded by viruses.
The ion channels coded by viruses.
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DOI：
10.1556/amicr.50.2003.4.9
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发表时间：
2003-01-01
影响因子：
1.5
通讯作者：
Ciampor, F.
中科院分区：
文献类型：
--
作者：
Ciampor, F.
致病性和毒力是多因素性状，取决于病毒与易感细胞和生物体的相互作用。由病毒编码的离子通道，病毒孔蛋白，仅代表参与病毒与细胞之间的级联相互作用的一个因子，导致病毒进入、复制和膜通透性的深刻变化。来自甲型流感病毒的M2蛋白形成参与调节囊泡pH的质子选择性pH调节通道，这是HA糖蛋白正确成熟的重要功能。流感B病毒的NB糖蛋白是具有离子通道活性的完整膜蛋白。C型流感病毒的CM 2蛋白是一种结构上类似于A型流感病毒M2和B型流感病毒NB蛋白的完整膜糖蛋白。小核糖核酸病毒3A蛋白参与细胞裂解，并显示与其他裂解蛋白的同源性。Vpu是由HIV-1编码的寡聚整合膜蛋白，形成离子通道。披膜病毒6 K蛋白与其他病毒孔蛋白具有结构相似性。
Pathogenicity and virulence are multifactorial traits, depending on interaction of viruses with susceptible cells and organisms. The ion channels coded by viruses, viroporins, represent only one factor taking part in the cascade of interactions between virus and cell, leading to the entry of virus, replication and to profound changes in membrane permeability. The M2 protein from influenza A virus forms proton-selective, pH-regulated channel involved in regulating vesicular pH, a function important for the correct maturation of HA glycoprotein. The NB glycoprotein of influenza B viruses is an integral membrane protein with an ion channel activity. The CM2 protein of influenza C virus is an integral membrane glycoprotein structurally analogous to influenza A virus M2 and influenza B virus NB proteins. The picornavirus 3A protein is involved in cell lysis and shows homology with other lytic proteins. Vpu is an oligomeric integral membrane protein encoded by HIV-1, which forms ion channels. The togavirus 6K protein shows structural similarities with other viroporins.