TRANSMISSIBLE AGENT IN NON-A, NON-B HEPATITIS
TRANSMISSIBLE AGENT IN NON-A, NON-B HEPATITIS
复制标题
DOI：
10.1016/s0140-6736(78)90131-9
复制
发表时间：
1978-03
期刊：
影响因子：
--
通讯作者：
H. Alter;P. Holland;R. Purcell;H. Popper
中科院分区：
文献类型：
--
作者：
H. Alter;P. Holland;R. Purcell;H. Popper
4例急性或慢性非甲非乙型输血后肝炎（P.T.H.）患者的血浆或血清还有一个与两起创伤后高压症有关的献血者接种到了5只黑猩猩身上。在这5只黑猩猩中出现了肝炎的生化和组织学证据，但在对照动物中没有。黑猩猩的平均潜伏期为13.4周，而4名PTH患者的平均潜伏期为7.7周。谷丙转氨酶峰值（A.L.T.）5只黑猩猩的水平分别为265、212、219、70和62 I.U./ L.组织学变化范围从轻度到明显的肝炎，通常与A.L.T.的程度相关。提升没有临床疾病的证据，所有动物继续进行生化和组织学恢复。无A型或B型肝炎的血清学证据。肝炎是由慢性和急性肝炎患者的血清传播的，强烈表明非甲非乙型肝炎的病原体是慢性携带者。因此，非甲非乙型肝炎似乎是由于一种可持续存在并长期保持传染性的传染性因子引起的。
Plasma or serum from 4 patients with acute or chronic non-A, non-B post-transfusion hepatitis (P.T.H.) and from a blood-donor implicated in two cases of P.T.H. was inoculated into 5 chimpanzees. Biochemical and histological evidence of hepatitis developed in these 5 chimpanzees but not in a control animal. The mean incubation period in the chimpanzees was 13·4 weeks, compared with 7·7 weeks in the 4 patients with P.T.H. The peak alanine aminotransferase (A.L.T.) levels in the 5 chimpanzees were 265, 212, 219, 70, and 62 I.U./l. Histological changes ranged from mild to conspicuous hepatitis and generally correlated with the degree of A.L.T. elevation. There was no evidence of clinical disease and all animals went on to biochemical and histological recovery. There was no serological evidence of type A or type B hepatitis. Hepatitis was transmitted by serum derived from patients with chronic as well as acute hepatitis, strongly suggesting a chronic carrier state for the agent responsible for non-A, non-B hepatitis. Non-A, non-B hepatitis thus seems to be due to a transmissible agent which can persist and remain infectious for long periods.