Quantitative measurement of cerebral haemodynamics in early vascular dementia and Alzheimer's disease
Quantitative measurement of cerebral haemodynamics in early vascular dementia and Alzheimer's disease
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DOI：
10.1016/j.jocn.2005.04.017
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发表时间：
2006-06-01
影响因子：
2
通讯作者：
Lovett, Elizabeth C.
中科院分区：
文献类型：
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作者：
Bateman, Grant A.;Levi, Christopher R.;Lovett, Elizabeth C.
阿尔茨海默病(AD)和血管性痴呆(VAD)都有显著的血管危险因素。本研究以绝对而非相对的方式测量这些疾病的血流动力学。24名患者被分为早期AD或VaD，并与12名非认知损害的受试者进行比较。采用磁共振成像血流定量技术测量动脉血流量和脉搏血容量。计算平均血管阻力和顺应性。AD组动脉流入较正常降低18%，阻力较正常增加23%，顺应性较正常降低20%(P=0.01、0.02、0.05)。VaD患者的动脉搏动容量较正常高24%，顺应性较正常高35%(p=0.03)。早期VaD的特点是血流正常，但脉搏增加。早期AD的特点是血流量减少和动脉树不顺应性。皇冠版权所有(C)2006由爱思唯尔有限公司出版。保留所有权利。
Alzheimer's disease (AD) and vascular dementia (VaD) both share significant vascular risk factors. The present study measures the haemodynamics of these diseases in absolute rather than relative terms. Twenty-four patients were classified as either early AD or VaD and were compared with 12 non-cognitively impaired subjects. Magnetic resonance imaging flow quantification was used to measure arterial inflow and arterial pulse volume. Mean vascular resistance and compliance were calculated. In AD, the arterial inflow was lower by 18%, resistance was higher by 23% and compliance of the arterial tree was lower by 20% compared with normal (P = 0.01, 0.02 and 0.05, respectively). In VaD, the arterial pulse volume was higher by 24% and compliance was higher by 35% compared with normal (p = 0.03 for both). Early VaD is characterized by normal blood flow, but increased pulsation. Reduced blood flow and an incompliant arterial tree characterize early AD. Crown Copyright (C) 2006 Published by Elsevier Ltd. All rights reserved.