Attention, memory, and motor skills as childhood predictors of schizophrenia-related psychoses: The New York high-risk project
Attention, memory, and motor skills as childhood predictors of schizophrenia-related psychoses: The New York high-risk project
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DOI：
10.1176/appi.ajp.157.9.1416
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发表时间：
2000-09-01
影响因子：
17.7
通讯作者：
Gottesman, II
中科院分区：
文献类型：
--
作者：
Erlenmeyer-Kimling, L;Rock, D;Gottesman, II
目的：儿童期神经行为缺陷的后代精神分裂症，情感疾病，精神正常的父母进行了评估作为预测的精神分裂症相关的精神病在adult.Method：后代进行了测试，在7-12岁的年龄和评估在成年中期轴I诊断的神经行为措施。儿童期注意力、言语记忆和粗大运动技能缺陷与成年期精神分裂症相关精神病的关系采用Logistic回归方程进行独立路径分析。敏感性和特异性确定为每个儿童dysfunctions.Results：精神分裂症父母的后代，儿童语言记忆，粗大运动技能和注意力的缺陷，分别确定83%，75%和58%，精神分裂症相关精神病的受试者，50%确定所有三个变量相结合。假阳性率在受试者谁没有发展精神分裂症相关的精神病范围从18%的缺陷，在儿童期的注意力和28%的缺陷，在记忆中的三个变量有较低的赤字率在后代的其他两个父母组，并没有与其他精神疾病在任何组。成年期精神分裂症相关精神病在精神分裂症风险受试者中的区别在于儿童期言语记忆、粗大运动技能和注意力的缺陷。研究结果表明，这些变量的缺陷是相对具体的精神分裂症的风险，并可能是精神分裂症的遗传易感性的指标。
Objective: Childhood neurobehavioral deficits in offspring of schizophrenic, affectively ill, and psychiatrically normal parents were evaluated as predictors of schizophrenia-related psychoses in adulthood.Method: The offspring were tested with neurobehavioral measures at 7-12 years of age and assessed in mid-adulthood for axis I diagnoses. The relationships of childhood deficits in attention, verbal memory and gross motor skills to adulthood schizophrenia-related psychoses were examined in separate path analyses by using logistic regression equations. Sensitivity and specificity were determined for each of the childhood dysfunctions.Results: For the offspring of schizophrenic parents, childhood deficits in verbal memory, gross motor skills, and attention identified 83%, 75%, and 58%, respectively, of the subjects with schizophrenia-related psychoses; 50% were identified by all three variables combined. False positive rates in subjects who did not develop schizophrenia-related psychoses ranged from 18% for those with deficits in attention during childhood to 28% for those with deficits in memory The three variables had low deficit rates in the offspring of the other two parental groups and were not associated with other psychiatric disorders in any group.Conclusions: Schinophrenia-related psychoses in adulthood are distinguished in subjects at risk for schizophrenia by childhood deficits in verbal memory, gross motor skills, and attention. The findings suggest that deficits in these variables are relatively specific to schizophrenia risk and may be indicators of the genetic liability to schizophrenia.