Non-cancer mortality among long-term survivors of adult cancer in Korea: national cancer registry study
Non-cancer mortality among long-term survivors of adult cancer in Korea: national cancer registry study
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DOI：
10.1007/s10552-010-9521-x
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发表时间：
2010-06-01
影响因子：
2.3
通讯作者：
Yun, Young Ho
中科院分区：
文献类型：
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作者：
Shin, Dong Wook;Ahn, Eunmi;Yun, Young Ho
为了调查韩国成年癌症长期存活者的非癌症死亡模式，并确定非癌症原因是否存在超额死亡，我们合并了国家癌症登记数据和国家死亡登记数据，以确定1993-2000年期间被诊断为癌症的243,713人的非癌症死亡模式，这些人的生存时间为千分之五。我们通过间接标准化方法计算标准化死亡率(SMR)。在截至2005年12月的患者中，26,498人(10.9%)死亡；其中6,364人(24.0%)的死亡原因不是癌症。非癌症死亡的比例随着确诊年龄的增加而增加，并与5年生存率相关(r=0.336，男性为0.571)。尽管长期存活者的非癌症死亡风险普遍较低(SMR，0.78；95%CI，0.76-0.80)，但年轻存活者的非癌症死亡风险(SMR，50岁前死亡者，SMR，1.23-2.50)高于普通人群。幸存者的自杀率较高(SMR，1.28；95%CI，1.15-1.42)，尤其是男性(SMR，1.35；95%CI，1.19-1.53)和胃癌幸存者(SMR，1.38；95%CI，1.14-1.66)。对于长期的成年癌症幸存者，特别是年轻的幸存者，有必要给予适当的医疗护理，以防止非癌症原因导致的过早死亡。
To investigate the pattern of non-cancer deaths and to determine whether there is excess mortality from non-cancer causes among Korean long-term survivors of adult cancer.We merged national cancer registry data and national death registration data to determine non-cancer death patterns of 243,713 people who were diagnosed with cancer from 1993 to 2000 and who survived a parts per thousand yen5 years. We calculated standardized mortality ratios (SMRs) by an indirect standardization method.Of the patient population, 26,498 (10.9%) had died as of December 2005; the cause of death for 6,364 (24.0%) of those was not cancer. The proportion of non-cancer mortality increased with age at diagnosis and correlated with the 5-year survival rate (r = 0.336 for women, 0.571 for men). Although the risk for non-cancer death was lower among long-term survivors in general (SMR, 0.78; 95% CI, 0.76-0.80), it was higher among younger survivors (SMR, 1.23-2.50, for those who died before 50) than the general population. Survivors had an elevated suicide rate (SMR, 1.28; 95% CI, 1.15-1.42), especially male (SMR, 1.35; 95% CI, 1.19-1.53) and stomach cancer survivors (SMR, 1.38; 95% CI, 1.14-1.66).Appropriate medical attention for long-term adult cancer survivors, especially younger survivors, is warranted to prevent premature deaths from non-cancer causes.