Antinociceptive synergy between Δ9-tetrahydrocannabinol and opioids after oral administration
Antinociceptive synergy between Δ9-tetrahydrocannabinol and opioids after oral administration
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DOI：
10.1124/jpet.102.045575
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发表时间：
2003-03-01
影响因子：
3.5
通讯作者：
McCarthy, EA
中科院分区：
文献类型：
--
作者：
Cichewicz, DL;McCarthy, EA
口服大麻素 Delta(9)-四氢大麻酚 (Delta(9)-THC) 可增强吗啡和可待因等阿片类药物对小鼠的镇痛作用。然而，尚未进行等效辐射分析来证实 Delta(9)-THC 与吗啡或可待因通过口服给药途径之间的协同作用。为了确定这些缓解疼痛的药物之间相互作用的性质并扩展之前的实验结果，我们进行了等辐射线分析，以评估甩尾测试中的加和性或协同作用。测试了 Delta(9)-THC 与吗啡或可待因的固定比例组合的抗伤害作用。使用等辐射线分析将每种组合的实验得出的 ED50 与理论加法 ED50 进行比较。所有测试的固定比例组合产生的镇痛作用（协同作用）比简单相加预测的要强。这些发现表明，使用低剂量镇痛药组合是治疗疼痛的有效方法，需要进一步研究。
The analgesic effects of opioids, such as morphine and codeine, in mice are enhanced by oral administration of the cannabinoid Delta(9)-tetrahydrocannabinol (Delta(9)-THC). However, isobolographic analysis has never been done to confirm a synergy between Delta(9)-THC and morphine or codeine via oral routes of administration. To determine the nature of the interaction between these drugs for pain relief and extend previous experimental results, we performed an isobolographic analysis to evaluate for additivity or synergy in the tail-flick test. Fixed-ratio combinations of Delta(9)-THC with either morphine or codeine were tested for antinociceptive effects. The experimentally derived ED50 for each combination was compared with the theoretical additive ED50, using an isobolographic analysis. All of the fixed-ratio combinations tested produced greater antinociception (synergy) than predicted from simple additivity. These findings suggest that the use of a low-dose combination of analgesics is a valid and effective approach for the treatment of pain and necessitates further study.