Dynamic TurboFLASH subtraction technique for contrast-enhanced MR imaging of the prostate: Correlation with histopathologic results
Dynamic TurboFLASH subtraction technique for contrast-enhanced MR imaging of the prostate: Correlation with histopathologic results
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DOI：
10.1148/radiology.203.3.9169683
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发表时间：
1997-06-01
期刊：
影响因子：
19.7
通讯作者：
Barentsz, JO
中科院分区：
文献类型：
--
作者：
Jager, GJ;Ruijter, ETG;Barentsz, JO
目得：要评估TurboFLASH是否（快速低角度拍摄）磁共振（MR）序列可以提高快速自旋回波（SE）直肠内线圈MR成像在前列腺癌分期和定位中的准确性。材料和方法：在57例前列腺癌患者中，采用以下序列进行MR成像：T1加权SE、T2加权快速SE、单节段钆增强动态减影TurboFLASH（每1.25或2.5秒一张图像）和晚期钆增强T1加权SE。回顾性研究，两名独立的盲读者对增强的开始和最陡斜率进行分级，并评估肿瘤累及和包膜穿透。结果：前列腺癌在TurboFLASH图像上表现为早期快速强化，且与周围组织相比，增强速度加快。两位读片员使用TurboFLASH图像检测肿瘤累及的平均灵敏度、特异性和准确性分别为73.5%、81.0%和77.5%。快速SE图像的这些值分别为57.5%、80.5%和72.0%。当TurboFLASH图像与快速SE图像一起包含时，对包膜穿透的描述以及肿瘤的描绘和分期会更好。然而，两种序列之间的差异无统计学意义。结论：由于TurboFLASH序列并没有统计学意义上显著改善肿瘤定位和分期结果，不建议常规使用。该技术可能是有用的，为选定的患者与模棱两可的证据囊渗透。
PURPOSE: To assess whether a TurboFLASH (fast low-angle shot) magnetic resonance (MR) sequence can improve the accuracy of fast spin-echo (SE) endorectal coil MR imaging in the staging and localization of prostate cancer.MATERIALS AND METHODS: In 57 patients with prostate cancer, MR imaging was performed with the following sequences: T1-weighted SE, T2-weighted fast SE, single-section gadolinium-enhanced dynamic subtracted TurboFLASH (one image every 1.25 or 2.5 seconds), and late-phase gadolinium-enhanced T1-weighted SE. Retrospectively, two blinded independent readers graded onset and steepest slope of enhancement and assessed tumor involvement and capsular penetration. MR findings were correlated with histopathologic results.RESULTS: On TurboFLASH images, prostate cancer was characterized by early and rapidly accelerating enhancement compared with that of surrounding tissues. Average sensitivity, specificity, and accuracy for detection of tumor involvement for the two readers with TurboFLASH images were 73.5%, 81.0%, and 77.5%. These values with fast SE images were 57.5%, 80.5%, and 72.0%. Depiction of capsular penetration and delineation and staging of tumor were better when TurboFLASH images were included with fast SE images. Differences between the two sequences, however, were not statistically significant.CONCLUSION: Because the TurboFLASH sequence did not statistically significantly improve tumor localization and staging results, routine use is not recommended. The technique may be useful for selected patients with equivocal evidence of capsular penetration.