Prospective evaluation of luteal phase length and natural fertility.
Prospective evaluation of luteal phase length and natural fertility.
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DOI：
10.1016/j.fertnstert.2016.11.022
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发表时间：
2017-03
影响因子：
6.7
通讯作者：
Steiner AZ
中科院分区：
文献类型：
--
作者：
Crawford NM;Pritchard DA;Herring AH;Steiner AZ
To evaluate the impact of a short luteal phase on fecundability. Prospective, time to pregnancy cohort study Community-based cohort Women trying to conceive, ages 30–44 years, without known infertility Daily diaries, ovulation prediction testing, standardized pregnancy testing Subsequent cycle fecundability 1,635 cycles from 284 women were included in the analysis. A short luteal phase (length of 11 days or less including the day of ovulation) occurred in 18% of observed cycles. Mean luteal phase length was 14 days. Significantly more women with a short luteal phase were smokers. After adjustment for age, women with a short luteal phase had 0.82 times the odds of pregnancy (95% CI: 0.46–1.47) in the subsequent cycle immediately following the short luteal phase when compared to women without a short luteal phase. Women with a short luteal length in the first observed cycle had significantly lower fertility after the first 6 months of pregnancy attempt, but at 12 months, there was no significant difference in cumulative probability of pregnancy. Although an isolated cycle with a short luteal phase may negatively impact short-term fertility, incidence of infertility at 12 months was not significantly higher among these women. A short luteal phase length may have negative impact on natural fertility.
