Photoacoustic spectrum analysis for microstructure characterization in biological tissue: A feasibility study
Photoacoustic spectrum analysis for microstructure characterization in biological tissue: A feasibility study
复制标题
用于生物组织微观结构表征的光声光谱分析：可行性研究
DOI：
10.1063/1.4768703
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发表时间：
2012-11-26
影响因子：
4
通讯作者：
Wang, Xueding
中科院分区：
文献类型：
--
作者：
Xu, Guan;Dar, Irfaan A.;Wang, Xueding
本研究探讨了通过分析来自组织的光声信号的频谱来表征生物组织内微观结构的可行性。假设来源于对感兴趣区域内光声源的尺寸/浓度与光声信号功率谱拟合的线性模型之间关系的理论分析。通过将聚乙烯微球包埋在猪明胶中制备的光声光谱模拟和实验，验证了上述假设，表明光声光谱分析可以作为表征生物样品微观结构的潜在工具。(C) 2012年美国物理研究所。[http://dx.doi.org/10.1063/1.4768703]
This study investigates the feasibility of characterizing the microstructures within a biological tissue by analyzing the frequency spectrum of the photoacoustic signal from the tissue. Hypotheses are derived from theoretical analyses on the relationships between the dimensions/concentrations of the photoacoustic sources within the region-of-interest and the linear model fitted to the power spectra of photoacoustic signals. The hypotheses are validated, following the procedures of ultrasound spectrum analysis, by simulations and experiments with phantoms fabricated by embedding the polyethylene microspheres in porcine gelatin, indicating that photoacoustic spectrum analysis could be a potential tool for characterizing microstructures in biological samples. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4768703]