Spectrum of retinal abnormalities in renal transplant patients using chronic low-dose steroids
Spectrum of retinal abnormalities in renal transplant patients using chronic low-dose steroids
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DOI：
10.1007/s00417-017-3823-6
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发表时间：
2017-12-01
影响因子：
2.7
通讯作者：
Boon, Camiel J. F.
中科院分区：
文献类型：
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作者：
van Dijk, Elon H. C.;Soonawala, Darius;Boon, Camiel J. F.
评估接受肾移植的无症状患者在检查前至少过去 2 年长期使用低剂量类固醇的眼科特征。横断面研究。所有患者均接受了广泛的眼科检查。这 37 名患者中 [25 名男性，12 名女性； 59 +/- 11 岁（范围，38-77 岁）] 眼科表型显示 22 名患者（59%）存在异常。在 10 名患者 (27%) 中检测到（亚临床）中心性浆液性脉络膜视网膜病变的特征，其中包括两名黄斑内有浆液性视网膜下液的患者。六名患者 (16%) 存在黄斑视网膜前膜。与无异常的患者相比，有眼科异常的患者的平均黄斑中心凹下脉络膜厚度显着增加。在大多数长期使用低剂量类固醇的肾移植患者中，视网膜异常很常见。这些视网膜变化可能与肾脏疾病和/或长期使用类固醇对脉络膜和视网膜的影响有关。
To assess the ophthalmological characteristics of asymptomatic patients with a renal transplant on chronic low-dose steroids for at least the last 2 years prior to examination.Cross-sectional study. All patients underwent an extensive ophthalmological examination.Of the 37 included patients [25 male, 12 female; 59 +/- 11 years (range, 38-77 years)] ophthalmological phenotyping revealed abnormalities in 22 patients (59%). Findings characteristic for (subclinical) central serous chorioretinopathy were detected in ten patients (27%), including two patients with serous subretinal fluid in the macula. An epiretinal membrane of the macula was present in six patients (16%). Mean subfoveal choroidal thickness was significantly increased in patients with ophthalmological abnormalities, in comparison with patients without abnormalities.Retinal abnormalities are common in the majority of renal transplant patients using chronic low-dose steroids. These retinal changes may be associated with the renal disease and/or the effect of chronic steroid use on the choroid and retina.