Who are the long-term survivors of recurrent ovarian carcinoma?: a retrospective analysis of a multicenter study
Who are the long-term survivors of recurrent ovarian carcinoma?: a retrospective analysis of a multicenter study
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谁是复发性卵巢癌的长期幸存者？：多中心研究的回顾性分析
DOI：
10.1007/s10147-022-02214-9
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发表时间：
2022
影响因子：
3.3
通讯作者：
Kajiyama Hiroaki
中科院分区：
文献类型：
--
作者：
Yoshihara Masato;Mogi Kazumasa;Kitami Kazuhisa;Uno Kaname;Iyoshi Shohei;Tano Sho;Fujimoto Hiroki;Miyamoto Emiri;Yoshikawa Nobuhisa;Emoto Ryo;Matsui Shigeyuki;Kajiyama Hiroaki
BackgroundThe的目的，本研究是调查复发性卵巢癌（LTSROC）的长期生存者的发病率和特点，在一个大规模的回顾性队列的患者从一个多中心研究group.MethodsWe进行了一项区域性多中心回顾性研究，1986年1月至2021年9月使用的临床数据收集的中央病理审查系统。在诊断时接受原发性OC手术并在初始治疗后发生复发肿瘤的患者被纳入。我们将LTSROC定义为最初肿瘤复发后存活5年或更长时间的患者，并检查影响ROC长期生存的因素和LTSROC.ResultsWe的结果收集恶性卵巢肿瘤患者的信息，并最终将657名开发ROC的患者纳入研究人群。68例（10.4%）患者为LTSROC，而399例（60.7%）为复发性卵巢癌的短期生存者。在多变量logistic回归分析中，阴性腹水细胞学[比值比（OR）1.865; 95%CI 1.026-3.393;p= 0.041]和1年或更长时间的无复发间隔（RFI）（OR 2.896; 95%CI 1.546-5.425;p< 0.001）被确定为与LTSROC相关的独立因素。约80%的LTSROC表现为孤立性复发肿瘤。此外，超过50%的LTSROC进行肿瘤减积手术的第一次复发肿瘤化疗或不。结论RFI的1年或更长时间和阴性腹水细胞学在首次手术LTSROC的独立预测因素。
BackgroundThe aim of the present study was to investigate the incidence and hallmarks of long-term survivors of recurrent ovarian carcinoma (LTSROC) in a large-scale retrospective cohort of patients from a multicenter study group.MethodsWe performed a regional multicenter retrospective study between January 1986 and September 2021 using clinical data collected under the central pathological review system. Patients who underwent surgery for primary OC at diagnosis and developed recurrent tumors after the initial treatment were included. We defined LTSROC as patients who survived for 5 years or longer after initial tumor recurrence and examined factors affecting the long-term survival of ROC and outcomes of LTSROC.ResultsWe collected information on patients with malignant ovarian tumors and finally 657 of them that developed ROC were included in the study population. Sixty-eight (10.4%) patients were LTSROC while 399 (60.7%) were short-term survivors of recurrent ovarian carcinoma. In a multivariate logistic regression analysis, negative ascites cytology [odds ratio (OR) 1.865; 95% CI 1.026–3.393;p= 0.041] and a recurrence-free interval (RFI) of 1 year or longer (OR 2.896; 95% CI 1.546–5.425;p< 0.001) were identified as independent factors associated with LTSROC. Approximately 80% of LTSROC presented with solitary recurrent tumors. Furthermore, more than 50% of LTSROC underwent tumor debulking surgery for the first recurrent tumor with or without chemotherapy.ConclusionRFI of 1 year or longer and negative ascites cytology in the initial surgery were identified as independent predictive factors for LTSROC.