Diagnosis and ultrasonographic appearance of hepatic metastasis in six cases of canine appendicular osteosarcoma (2005-2013)
Diagnosis and ultrasonographic appearance of hepatic metastasis in six cases of canine appendicular osteosarcoma (2005-2013)
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DOI：
10.1111/avj.12435
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发表时间：
2016-05-01
影响因子：
1.1
通讯作者：
Fan, T. M.
中科院分区：
文献类型：
--
作者：
Cesario, L.;Garrett, L. D.;Fan, T. M.
ObjectivesThe的目的，这项回顾性研究的目的是确定临床病例的狗与apapricular骨肉瘤（OSA），其中肝转移被证实，突出使用细胞学诊断和描述的放射影像学和超声表现的lecture.MethodsMedical记录进行了回顾性审查的狗与apricular OSA和肝转移瘤之间的2005年1月至2013年1月。X线片，超声和细胞学的审查performed.Results6狗apapellular OSA和肝转移。转移灶的声像图表现多样，包括高回声伴阴影、高回声不伴阴影、低回声及混合回声。在2例病例中，胸部X线片也显示肝转移。从诊断为非典型性OSA开始的平均生存时间为188天（范围69-363天），从诊断为肝转移开始的平均生存时间为35天（范围2-69天）。死亡是肿瘤相关的所有cases.ConclusionsHepatic转移瘤变化很大，在其超声表现。在6例病例中，有3例发现肝转移，而没有并发肺转移;因此，定期进行腹部超声检查可能有助于患者评估，特别是在临床试验中，准确识别无病期至关重要。一旦证实肝转移，生存时间似乎有限。
ObjectivesThe aims of this retrospective study were to identify clinical cases of dogs with appendicular osteosarcoma (OSA) in which hepatic metastasis was confirmed, to highlight the use of cytology for its diagnosis and to describe the radiographic and ultrasonographic appearances of the lesion.MethodsMedical records were retrospectively reviewed for dogs with appendicular OSA and hepatic metastases between January 2005 and January 2013. Reviews of radiographs, ultrasounds and cytology were performed.ResultsSix dogs with appendicular OSA and hepatic metastases were identified. The ultrasonographic appearance of metastatic lesions varied, including hyperechoic with shadowing, hyperechoic without shadowing, hypoechoic and mixed echogenicity. In two cases, the hepatic metastases were also evident on thoracic radiographs. The mean survival time from diagnosis of appendicular OSA was 188 days (range 69-363 days) and from diagnosis of hepatic metastases was 35 days (range 2-69 days). Death was tumour-related in all cases.ConclusionsHepatic metastasis varies widely in its ultrasonographic appearance. In three of six cases, hepatic metastasis was identified without concurrent pulmonary metastasis; therefore, abdominal ultrasound may be useful at regular intervals for patient evaluation, especially in clinical trials where accurate identification of the disease-free interval is crucial. Once hepatic metastasis is confirmed, survival times appear limited.