Synthesis of fibronectin in normal and osteoarthritic articular cartilage.
Synthesis of fibronectin in normal and osteoarthritic articular cartilage.
复制标题
正常和骨关节炎关节软骨中纤连蛋白的合成。
DOI：
10.1016/0304-4165(84)90093-x
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Lust,G
中科院分区：
文献类型：
--
作者：
Wurster,NB;Lust,G
The content and the biosynthesis of fibronectin was examined in disease-free articular cartilage and in articular cartilage from osteoarthritic canine joints. Fibronectin content was increased in extracts of cartilage from osteoarthritic joints. Incubation of cartilage in vitro with [3H]phenylalanine and subsequent isolation of [3H]fibronectin from a gelatin affinity column and characterization by SDS-polyacrylamide gel electrophoresis and by immunoprecipitation indicated that disease-free and osteoarthritic cartilage explants synthesized fibronectin. About 50% of the [3H]fibronectin was recovered in the incubation medium. The osteoarthritic cartilage synthesized and accumulated up to 5-fold more [3H]fibronectin than disease-free cartilage.
