Autophagic and apoptotic response to stress signals in mammalian cells
Autophagic and apoptotic response to stress signals in mammalian cells
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DOI：
10.1016/j.abb.2007.02.006
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发表时间：
2007-06-15
影响因子：
3.9
通讯作者：
Cecconi, Francesco
中科院分区：
文献类型：
--
作者：
Ferraro, Efisabetta;Cecconi, Francesco
自噬是一种高度保守的降解蛋白质和细胞器的分解代谢程序。这一过程已被证明在不同的生理和病理条件下作为促生存或促死亡机制。一些应激刺激可以诱导自噬，例如营养剥夺或低等和高等真核生物发育中的关键步骤。细胞凋亡是一种精心策划的细胞死亡形式，其中细胞积极参与其自身的死亡。同样，应激是细胞凋亡的正调节剂，特别是其线粒体介导的线粒体途径。除了讨论哺乳动物中参与自噬的关键分子在应激信号中所起的作用外，我们还讨论了在这些条件下自噬和凋亡之间的相互关系。(C)2007年爱思唯尔公司All rights reserved.
Autophagy is a highly conserved catabolic programme for degrading proteins and organelles. This process has been shown to act as a pro-survival or pro-death mechanism in different physiological and pathological conditions. Several stress stimuli can induce autophagy, such as nutrient deprivation or critical steps in development of lower and higher eukaryotes. Apoptosis is an orchestrated form of cell death in which cells are actively involved in their own demise. Again, stress is a positive regulator of apoptosis and, in particular, of its apoptosome-mediated mitochondrial pathway. Besides discussing the individual roles played by the key molecules involved in autophagy in mammals in response to stress signals, we discuss here the interrelations between autophagy and apoptosis under these conditions. (C) 2007 Elsevier Inc. All rights reserved.