A Complex Automata approach for in-stent restenosis: Two-dimensional multiscale modelling and simulations
A Complex Automata approach for in-stent restenosis: Two-dimensional multiscale modelling and simulations
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DOI：
10.1016/j.jocs.2010.09.002
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发表时间：
2011-03-01
影响因子：
3.3
通讯作者：
Hoekstra, Alfons
中科院分区：
文献类型：
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作者：
Caiazzo, Alfonso;Evans, David;Hoekstra, Alfons
支架内再狭窄是血管对支架展开造成的损伤的适应不良反应，是一个涉及大量生物和物理过程的多尺度系统。我们描述了用于支架内再狭窄的复杂自动机模型，耦合总体流量、药物扩散和平滑肌细胞模型，所有模型都在不同的时间尺度上运行。描述了单尺度模型和耦合接口的细节，以及通过复杂自动机模拟的专用软件环境获得的首次模拟结果。初步结果表明，该模型可以重现实验研究中观察到的增长趋势，并有助于检验有关关键因素相互作用的假设。 (C) 2011 Elsevier B.V. 保留所有权利。
In-stent restenosis, the maladaptive response of a blood vessel to injury caused by the deployment of a stent, is a multiscale system involving a large number of biological and physical processes. We describe a Complex Automata model for in-stent restenosis, coupling bulk flow, drug diffusion, and smooth muscle cell models, all operating on different time scales. Details of the single scale models and of the coupling interfaces are described, together with first simulation results, obtained with a dedicated software environment for Complex Automata simulations. Preliminary results show that the model can reproduce growth trends observed in experimental studies and facilitate testing of hypotheses concerning the interaction of key factors. (C) 2011 Elsevier B.V. All rights reserved.