Elevated RON protein expression in endometriosis and disease-associated ovarian cancers
Elevated RON protein expression in endometriosis and disease-associated ovarian cancers
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子宫内膜异位症和疾病相关卵巢癌中 RON 蛋白表达升高
DOI：
10.1007/s00404-016-4248-x
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发表时间：
2017
影响因子：
2.6
通讯作者：
Zhang Xinmei
中科院分区：
文献类型：
--
作者：
Xu Ping;Ding Shaojie;Zhu Libo;Le Fang;Huang Xiufeng;Tian Yonghong;Zhang Xinmei
研究背景RON蛋白的表达与肿瘤的进展、转移和预后密切相关，在深度浸润性子宫内膜异位症中，RON的mRNA表达水平升高。方法采用免疫组织化学(IHC)法检测正常子宫内膜(n=19)、在位子宫内膜(n=16)、异位内膜(n=51)以及子宫内膜异位症相关卵巢癌(EAOC，n=16)组织中RON蛋白的表达。EAOC表现出较高的RON蛋白水平。卵巢上皮性癌组织中RON蛋白表达频率和积分均显著高于子宫内膜异位症组[100.0%(14/14)，5.37±0.74；51.0%(26/51)，2.15±1.12；P=0.002，0.001]。多因素协方差分析仅显示RON蛋白表达与EAOC有关(P=0.006.0 5)，而与临床参数无关(P&>0.0 5)。结论RON蛋白表达增加可能参与了子宫内膜异位症和卵巢癌的发病机制。
BackgroundRecepteur d’origine nantais (RON) protein expression has been demonstrated to correlate with tumor progression, metastasis, and prognosis, and its mRNA expression increases in deeply infiltrating endometriotic lesions. However, it remains unclear whether RON protein expression also increases in endometriotic lesions, and may be a risk factor of malignant transformation in endometriotic lesions.MethodsThe protein expression of RON in control (n= 19), eutopic (n= 16), and ectopic (n= 51) endometria, as well as in endometriosis-associated ovarian cancers (EAOC,n= 16) was determined by immunohistochemical (IHC) staining.ResultsEndometriotic lesions expressed low levels of RON protein, but no RON protein expression appeared in matched eutopic or control endometrium. EAOC exhibited high levels of RON protein. The frequency and IHC score of RON protein expression were both significantly higher in EAOC [100.0% (14/14), 5.37 ± 0.74] than those in endometriotic lesions [51.0% (26/51), 2.15 ± 1.12;P= 0.002, 0.001]. Multivariate analysis of covariance only revealed a correlation of RON protein expression and EAOC (P= 0.006), but no correlations of RON protein expression and clinical parameters (P> 0.05).ConclusionsThese obtained results suggest that increased RON expression might be involved in the pathogenesis of endometriosis and disease-associated ovarian cancers.