PHYSICAL-ACTIVITY AND STROKE RISK - THE FRAMINGHAM-STUDY
PHYSICAL-ACTIVITY AND STROKE RISK - THE FRAMINGHAM-STUDY
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DOI：
10.1093/oxfordjournals.aje.a117298
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发表时间：
1994-10-01
影响因子：
5
通讯作者：
KANNEL, WB
中科院分区：
文献类型：
--
作者：
KIELY, DK;WOLF, PA;KANNEL, WB
作者前瞻性地研究了增加体力活动水平对弗雷明翰研究队列成员中风风险的影响。进行了两项独立的分析，一项是在1,897名男性(平均年龄=49.7岁)和2,299名女性(平均年龄=49.9岁)的中年时期，另一项是在队列年龄较大时(1,361名男性(平均年龄=63.0岁，1,862名女性(平均年龄=63.7岁))。一份结构化的问卷进行了两次独立的检查，用来估计在典型的24小时内完成的代谢工作量。将体力活动分为三级，将中等水平和高水平的体力活动与低水平的体力活动进行比较，作为参照组。使用COX比例风险、寿命表和时间依赖协变量分析来检验32年随访期间体力活动水平和卒中风险之间的关系。在男性中，调整后的分析显示，增加体力活动水平是有保护作用的。从一项涉及中三分位数年龄较大的队列成员的分析中获得了最强的效果(风险比=0.41，95%可信区间0.24-0.69)。高水平的体力活动不会比中等水平的体力活动带来额外的好处。调整后的分析显示，对女性没有显著的保护作用。这些结果表明，与低水平的体力活动相比，中等水平和高水平的男性体力活动对中风具有保护作用。
The authors prospectively examined the influence of increased levels of physical activity on risk of stroke in members of the Framingham Study cohort. Two separate analysis were performed, one during midlife in 1,897 men (mean age = 49.7 years) and 2,299 women (mean age = 49.9 years) and another when the cohort was older (1,361 men (mean age = 63.0 and 1,862 women (mean age = 63.7)). A structured questionnaire administered two separate examinations was used to estimate the amount of metabolic work done during a typical 24-hour period. Physical activity was categorized into tertiles, and medium and high levels of physical activity were compared with a low level of physical activity, which was used as the referent group. Cox proportional hazards, life table, and time-dependent covariate analysis were used to examine the relation between level of physical activity and stroke risk over a follow-up period of 32 years. In men, adjusted analyses revealed that increased levels of physical activity were protective. The strongest effect was obtained from an analysis involving older cohort members in the medium tertile (risk ratio = 0.41, 95% confidence interval 0.24-0.69). High levels of physical activity did not confer an additional benefit over medium levels. Adjusted analysis showed no significant protective effect in women. These results indicate that medium and high levels of physical activity among men are protective against stroke relative to low levels.