Segmentally restricted, cephalic expression of a leucine zipper gene during Drosophila embryogenesis.
Segmentally restricted, cephalic expression of a leucine zipper gene during Drosophila embryogenesis.
复制标题
果蝇胚胎发生过程中亮氨酸拉链基因的节段限制性头部表达。
DOI：
10.1016/0925-4773(91)90086-l
复制
发表时间：
1991
影响因子：
2.6
通讯作者：
Epstein,A
中科院分区：
文献类型：
--
作者：
Mohler,J;Vani,K;Leung,S;Epstein,A
一个新发现的基因CnC的表达模式和DNA序列表明，该基因在果蝇胚胎发育过程中的头部模式中发挥了作用。原位杂交显示转录本定位于下颌节段以及下咽和唇原基，首次在胚芽晚期被检测到。序列分析表明，该基因产物与亮氨酸拉链(BZIP)类转录因子有关。根据其蛋白质序列，我们认为CnC是参与控制头部形态发生的异源二聚体调节蛋白的一个亚基。
The expression pattern and DNA sequence of a newly identified gene, CNC (cap'n'collar), suggest a role for this gene in cephalic patterning during Drosophila embryogenesis. In situ hybridization reveals transcripts localized to the mandibular segment and the hypopharyngeal and labral primordia first detectable in late blastoderm stages. Sequence analysis of cDNA clones from the CNC locus shows the CNC gene product to be related to transcription factors of the leucine zipper (bZIP) class. Based on its protein sequence, we propose that CNC is a subunit of a heterodimeric regulatory protein involved in the control of head morphogenesis.