Postprandial natriuresis in humans: Further evidence that urodilatin, not ANP, modulates sodium excretion
Postprandial natriuresis in humans: Further evidence that urodilatin, not ANP, modulates sodium excretion
复制标题
DOI：
10.1152/ajprenal.1996.270.2.f301
复制
发表时间：
1996-02-01
期刊：
影响因子：
--
通讯作者：
Goetz, K
中科院分区：
文献类型：
--
作者：
Drummer, C;Franck, W;Goetz, K
我们研究了12名健康男性直立受试者高盐(100 Mmol)和低盐(5 Mmol)膳食对肾脏钠和氯排泄的影响。我们还测定了尿扩张素[ANP-(95-126)]的排泄量，以及血浆或血清心钠素[ANP-(99-126)]、醛固酮和肾素的浓度。高盐餐可引起餐后钠尿(餐后3h尿钠排泄量由59.0增加到204.6µm o l/m in)和氯离子排泄。同时，尿扩张素排泄量由35.7增加到峰值105fmol/min。高盐摄入对尿钠、氯化物和尿扩张素排泄量的影响显著(方差分析，P<；0.01)，且尿扩张素与钠排泄量(平均R=0.702)、尿扩张素与氯化物排泄量(平均R=0.776)密切相关。相比之下，血浆ANP在高盐摄入后15分钟急剧升高，1小时后已恢复到低盐水平。它与餐后钠尿谱不平行，也没有观察到血浆心钠素与钠排泄呈正相关。这些结果提供了进一步的证据，表明尿扩张素，而不是心钠素，是这个多肽家族的成员，主要参与调节钠和氯的排泄。
We examined the effects of a high-salt (100 mmol NaCl) and a low-salt (5 mmol NaCl) meal on the renal excretion of sodium and chloride in 12 healthy male upright subjects. We also measured the urinary excretion of urodilatin [ANP-(95-126)], and the plasma or serum concentrations of atrial natriuretic peptide [ANP-(99-126)], aldosterone, and renin. The high-salt meal produced a postprandial natriuresis (urinary sodium excretion from 59.0 to a peak rate of 204.6 mu mol/min in 3rd h after ingestion of meal) and chloride excretion. In parallel, the urinary excretion of urodilatin increased from 35.7 to a peak rate of 105 fmol/min. The effect of high-salt intake on urinary sodium, chloride, and urodilatin excretion was significant (analysis of variance, P < 0.01), and close significant correlations were observed between urodilatin and sodium excretion (mean R = 0.702) as well as between urodilatin and chloride excretion (mean R = 0.776). In contrast, plasma ANP, which was acutely elevated 15 min after high-salt intake, was already back to low-salt values 1 h later. It did not parallel the postprandial natriuretic profile, and no positive correlation between plasma ANP and sodium excretion was observed. These results provide further evidence that urodilatin, not ANP, is the member of this peptide family primarily involved in the regulation of the excretion of sodium and chloride.