Zebrafish: Model for the Study of Inflammation and the Innate Immune Response to Infectious Diseases
Zebrafish: Model for the Study of Inflammation and the Innate Immune Response to Infectious Diseases
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DOI：
10.1007/978-1-4614-0106-3_15
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发表时间：
2012-01-01
期刊：
影响因子：
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通讯作者：
Figueras, Antonio
中科院分区：
文献类型：
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作者：
Novoa, Beatriz;Figueras, Antonio
斑马鱼（Danio rerio）作为研究脊椎动物发育和造血的模型已被广泛用于生物医学研究，最近，它已被应用于包括免疫学在内的各个领域。受精后，由于适应性免疫系统在受精后4-6周才在形态和功能上成熟，因此幼虫仅以先天免疫应答存活。这种时间上的分离提供了一个合适的系统来研究脊椎动物体内的先天免疫应答，独立于适应性免疫应答。早期生命阶段的透明度允许有用的实时可视化。具有完整（先天和适应性）免疫系统的成年斑马鱼也提供了优于其他脊椎动物感染模型的优势：体积小，生命周期相对较快，易于繁殖，以及越来越多的用于研究传染病的分子工具。在这篇综述中，我们试图给出一些例子，斑马鱼作为一个有价值的模型在先天免疫和炎症研究的潜力。
The zebrafish (Danio rerio) has been extensively used in biomedical research as a model to study vertebrate development and hematopoiesis and recently, it has been adopted into varied fields including immunology. After fertilization, larvae survive with only the innate immune responses because adaptive immune system is morphologically and functionally mature only after 4-6 weeks postfertilization. This temporal separation provides a suitable system to study the vertebrate innate immune response in vivo, independently from the adaptive immune response. The transparency of early life stages allows a useful real-time visualization. Adult zebrafish which have complete (innate and adaptative) immune systems offer also advantages over other vertebrate infection models: small size, relatively rapid life cycle, ease of breeding, and a growing list of molecular tools for the study of infectious diseases. In this review, we have tried to give some examples of the potential of zebrafish as a valuable model in innate immunity and inflammation studies.