Side effects of anti-TNF therapy: current knowledge.
Side effects of anti-TNF therapy: current knowledge.
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DOI：
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发表时间：
2002-11
影响因子：
3.7
通讯作者：
C. Antoni;J. Braun
中科院分区：
文献类型：
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作者：
C. Antoni;J. Braun
抗肿瘤坏死因子治疗的发展是风湿性疾病治疗的一个里程碑。与所有新的治疗机会一样，在导致药物批准的临床试验中是否评估了所有潜在的不良副作用，这是值得关注的。上市后经验和药物警戒计划是必要的，以确定新药物的总体安全性特征。从最初几年的临床试验和实践经验中，我们知道在使用抗TNF药物治疗的患者中发生了副作用。对于使用这些非常有效的生物药物治疗患者的风湿病学家来说，充分了解这些部分特异性副作用至关重要。
The development of the anti-TNF therapies is a milestone in the therapy of rheumatic diseases. As in all new treatment opportunities it is of concern whether all potential undesired side effects have been evaluated within the clinical trials which have lead to approval of the drugs. Postmarketing experience and pharmacovigilance programs are necessary to determine the overall safety profile of the new agents. From the clinical trials and the practical experience of the first years we know that side effects have occurred in patients treated with anti-TNF agents. Sufficient knowledge about these partly specific side effects is critical for rheumatologists who treat their patients with these very effective biologic drugs.