Fifteen-minute consultation: An approach to the child receiving glucocorticoids.
Fifteen-minute consultation: An approach to the child receiving glucocorticoids.
复制标题
十五分钟咨询：儿童接受糖皮质激素的方法。
DOI：
10.1136/archdischild-2019-317812
复制
发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Kanthagnany SK
中科院分区：
文献类型：
--
作者：
Kanthagnany SK
糖皮质激素（GC）在儿科实践中用于广泛的条件，所有儿科医生在其职业生涯中都会以某种形式处方GC。各种GC制剂、剂量和给药途径可用于数天至数年的时间段。暴露于外源性GC可导致下丘脑-垂体-肾上腺轴抑制，也称为肾上腺抑制（AS）。AS患者大部分时间可能是健康的，但如果减少或停止GC治疗，或者如果在疾病期间不能产生额外的内源性GC，那么绝对或相对缺乏GC可能导致严重疾病或死亡。在这里，我们通过概述背景并讨论该临床实体的介绍和管理方法，强调AS与所有儿科医生的相关性。
Glucocorticoids (GC) are used in paediatric practice for a broad range of conditions and all paediatricians will prescribe GC, in some form, during their career. A wide variety of GC formulations, doses and administration routes are used for periods of time ranging from days to years. Exposure to exogenous GC can result in hypothalamic-pituitary-adrenal axis suppression—otherwise known as adrenal suppression (AS). Patients with AS may be well most of the time but if GC therapy is reduced or stopped or if additionalendogenousGC cannot be generated during illness, then an absolute or relative lack of GC can result in severe illness or death. Here, we highlight the relevance of AS to all paediatricians by providing an overview of the background and discussing the presentation and approaches to the management of this clinical entity.