Shaped stimuli-responsive hydrogel particles: syntheses, properties and biological responses.
Shaped stimuli-responsive hydrogel particles: syntheses, properties and biological responses.
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DOI：
10.1039/c6tb02746f
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发表时间：
2017-01
期刊：
影响因子：
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通讯作者：
Bing Xue;V. Kozlovskaya;E. Kharlampieva
中科院分区：
文献类型：
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作者：
Bing Xue;V. Kozlovskaya;E. Kharlampieva
产生具有明确形状的纳米和微米尺寸的水凝胶基质的能力可以提供一种强大的手段，不仅可以模拟生物系统的关键特性，而且可以调节形状依赖性颗粒生物分布和细胞缔合，并相应地优化药物递送载体。本文综述了从填充多孔网络到中空胶囊的非球形刺激响应性水凝胶颗粒。我们总结了目前的实验方法，并讨论了在颗粒水凝胶的形状和刺激响应的协同组合的发展前景。介绍了非球形pH、氧化还原、温度、机械力、磁性和酶响应性水凝胶粒子的设计和合成的最新进展。现有的和新兴的技术，用于创建各种形状的控制水凝胶的组成和大小的例子突出显示。我们还讨论了形状对这些颗粒的理化性质的影响，以及它们的形状调节的生物相互作用，包括颗粒循环时间和生物分布。
The ability to create nano- and micro-sized hydrogel matrices of well-defined shapes can provide a powerful means not only to mimic the key properties of biological systems, but also to regulate shape-dependent particle biodistribution and cellular association, and to correspondingly optimize drug delivery carriers. This review focuses on stimuli-responsive hydrogel particles of non-spherical shapes ranging from filled porous networks to hollow capsules. We summarize a pool of current experimental approaches and discuss perspectives in the development of the synergistic combination of shape and stimuli-response in particulate hydrogels. Recent advances in the design and synthesis of the pH-, redox-, temperature-sensitive, mechanical force-, magnetic- and enzyme-responsive hydrogel particles of non-spherical shapes are presented. Examples of existing and emerging technologies for creating a variety of shapes with controlled hydrogel composition and size are highlighted. We also discuss the effects of shape on the physiochemical properties of these particles as well as their shape-regulated biological interactions including particle circulation time and biodistribution.