Fragments generated upon extracellular matrix remodeling: Biological regulators and potential drugs
Fragments generated upon extracellular matrix remodeling: Biological regulators and potential drugs
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DOI：
10.1016/j.matbio.2017.11.005
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发表时间：
2019-01-01
期刊：
影响因子：
6.9
通讯作者：
Vallet, Sylvain D.
中科院分区：
文献类型：
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作者：
Ricard-Blum, Sylvie;Vallet, Sylvain D.
几种蛋白酶家族对细胞外基质（ECM）的重塑释放出许多生物活性片段，其调节许多生物学过程，如自噬、血管生成、脂肪生成、纤维化、肿瘤生长、转移和伤口愈合。本文综述了产生生物活性ECM片段的蛋白酶、ECM底物、主要生物活性ECM片段及其生物学特性和受体。ECM片段转化为药物具有挑战性，并且将利用综合方法来优化临床前和临床研究的设计。这可以通过构建ECM片段库（包括其亲本蛋白、重塑蛋白酶及其受体）的情境化相互作用网络以及通过使用数学疾病模型来完成。(C)2017爱思唯尔B.V.保留所有权利。
The remodeling of the extracellular matrix (ECM) by several protease families releases a number of bioactive fragments, which regulate numerous biological processes such as autophagy, angiogenesis, adipogenesis, fibrosis, tumor growth, metastasis and wound healing. We review here the proteases which generate bioactive ECM fragments, their ECM substrates, the major bioactive ECM fragments, together with their biological properties and their receptors. The translation of ECM fragments into drugs is challenging and would take advantage of an integrative approach to optimize the design of pre-clinical and clinical studies. This could be done by building the contextualized interaction network of the ECM fragment repertoire including their parent proteins, remodeling proteinases, and their receptors, and by using mathematical disease models. (C) 2017 Elsevier B.V. All rights reserved.