Circulating concentrations of proinflammatory cytokines in mild or moderate heart failure secondary to ischemic or idiopathic dilated cardiomyopathy
Circulating concentrations of proinflammatory cytokines in mild or moderate heart failure secondary to ischemic or idiopathic dilated cardiomyopathy
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DOI：
10.1016/s0002-9149(97)89206-5
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发表时间：
1996-04-01
影响因子：
2.8
通讯作者：
Gilbert, EM
中科院分区：
文献类型：
--
作者：
Munger, MA;Johnson, B;Gilbert, EM
促炎细胞因子能够通过多种机制调节心血管功能。这些细胞因子在重度心力衰竭患者中升高，但轻度或中度心力衰竭的变化尚未报道。因此，同时动脉和冠状窦浓度的白细胞介素-1 α，可溶性白细胞介素-2受体，白细胞介素-6。测定了78例纽约心脏协会心功能分级为II ~ IV级的心力衰竭患者的血浆TNF-α和TNF-α水平，并与17例健康志愿者进行了比较。白细胞介素-1 α、可溶性白细胞介素-2受体和白细胞介素-6的浓度通过“夹心"酶联免疫吸附试验测定，肿瘤坏死因子-α通过组织培养技术测定。轻度至中度心力衰竭患者与对照组相比，白细胞介素-1 α、可溶性白细胞介素-2受体或肿瘤坏死因子-α浓度无统计学差异。白细胞介素-6显著升高，75 +/- 16 vs 0.4 +/- 0.4 pg/ml（p = 0.002）。细胞因子浓度没有不同的心力衰竭病因。配对动脉和冠状窦浓度无显著差异。可溶性白细胞介素2受体浓度与纽约心脏协会心功能分级显著相关（r = 0.59，p = 0.04），与运动耐量时间呈负相关（r =-0.59，p = 0.007）。因此，白细胞介素-6在轻度或中度心力衰竭中显著升高。
Proinflammatory cytokines are capable of modulating cardiovascular function by a variety of mechanisms. These cytokines are elevated in patients with severe heart failure, but changes in mild or moderate heart failure have not been reported. Therefore, simultaneous arterial and coronary sinus concentrations of interleukin-1 alpha, soluble interleukin-2 receptor, interleukin-6. and tumor necrosis factor-alpha were measured in 78 patients with New York Heart Association functional class II to IV heart failure and compared with 17 healthy volunteers. Concentrations of interleukin-1 alpha, soluble interleukin-2 receptor, and interleukin-6 were determined by a ''sandwich'' enzyme-linked immunosorbent assay and tumor necrosis factor-alpha by tissue culture technique. There were no statistical differences in interleukin-1 alpha, soluble interleukin-2 receptor, or tumor necrosis factor-alpha concentrations in mild to moderate heart failure versus control subjects. Interleukin-6 was significantly elevated, 75 +/- 16 versus 0.4 +/- 0.4 pg/ml (p = 0.002). Cytokine concentrations did not differ by heart failure etiology. Paired arterial and coronary sinus concentrations were not significantly different. Soluble interleukin-2 receptor concentrations were significantly correlated with New York Heart Association functional class (r = 0.59, p = 0.04) and negatively associated with exercise tolerance time (r = -0.59, p = 0.007). Thus, interleukin-6 is significantly elevated in mild or moderate heart failure.