The 5HT1A receptor: Signaling, desensitization, and gene transcription
The 5HT1A receptor: Signaling, desensitization, and gene transcription
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DOI：
10.1016/s0893-133x(96)80055-8
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发表时间：
1996-01-01
影响因子：
7.6
通讯作者：
Saucier, C
中科院分区：
文献类型：
--
作者：
Albert, PR;Lembo, P;Saucier, C
The hypothesis that antianxiety or antidepressant agents (e.g., 5-HT1A agonists, 5-HT uptake blockers) exert their clinical actions via enhancement of serotonergic neurotransmission due to desensitization of 5-HT1A autoreceptors predicts that regulation of this receptor plays a crucial role in the therapeutic actions of these agents. A multidisciplinary strategy is described for the characterization of the 5-HT1A receptor at the level of cellular signaling mechanisms and genetic regulation, using heterologous expression of the cloned receptor in cell lines, site-directed mutagenesis, isolation of receptor-positive neuronal cell lines, and promoter analysis of the 5-HT1A receptor gene. These analyses will yield new insights into the possible mechanisms down-regulation of 5-HT1A receptor signaling, and may suggest novel sites of inherent defect involved in anxiety syndromes or major depression.
