Characteristics of circle of Willis variations in the mongolian gerbil and a newly established ischemia-prone gerbil group.
Characteristics of circle of Willis variations in the mongolian gerbil and a newly established ischemia-prone gerbil group.
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DOI：
10.1093/ilar.52.1.e1
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发表时间：
2011
期刊：
影响因子：
2.5
通讯作者：
Xiaoyan Du;X. Zhu;Gang Dong;Jing Lu;Ying Wang;Lin Zeng;Taiyun Zhao;Hua-hu Ye;Ruisheng Li;Jie Bai;Zhen Chen
中科院分区：
文献类型：
--
作者：
Xiaoyan Du;X. Zhu;Gang Dong;Jing Lu;Ying Wang;Lin Zeng;Taiyun Zhao;Hua-hu Ye;Ruisheng Li;Jie Bai;Zhen Chen
蒙古沙鼠（Meriones unguiculatus）有一个不完整的威利斯圈（CoW），因此大约30-40%的蒙古沙鼠在单侧颈动脉闭塞（UCO）后发生局灶性脑缺血。CoW的前后交通动脉（分别为ACoAs和PCoAs）有四种类型，它们决定了缺血性症状的严重程度。我们使用了来自五代的398只沙鼠，包括一个选择性繁殖的易缺血组，来研究uco后的缺血症状和父母及其后代之间ACoA和PCoA模式的可能相关性。我们观察到，如果父母有完整的ACoA，他们的后代也有完整的ACoA，当父母的ACoA不完整时，我们发现有显著差异：60.4%的后代的ACoA类型与母亲一致，48.2%的后代与父亲一致。当pcoa缺失时，UCO后神经系统症状的严重程度与acoa的模式显著相关。不完全acoa沙鼠的UCO缺血比例明显高于完全acoa沙鼠。经过5代的选择性育种，UCO缺血的比例从F1动物的40%增加到F5动物的75%。我们的研究结果表明，CoW的变异是遗传的，并表明我们成功地建立了一个容易缺血的沙鼠群体。
Mongolian gerbils (Meriones unguiculatus) have an incomplete circle of Willis (CoW), as a result of which approximately 30-40% of these animals develop focal cerebral ischemia after unilateral carotid occlusion (UCO). There are four types of patterns of the anterior and posterior communicating arteries (ACoAs and PCoAs, respectively) of the CoW and they determine the severity of the ischemic symptoms. We used 398 gerbils from five generations, including a selectively bred ischemia-prone group, to investigate post-UCO ischemic symptoms and possible correlations of ACoA and PCoA patterns between parents and their progeny. We observed that if the parents had complete ACoAs, their progeny also had complete ACoAs, and we found significant differences when the parents' ACoAs were incomplete: in 60.4% of offspring the type of ACoA was consistent with that of the mother and in 48.2% it was consistent with that of the father. The severity of the neurological symptoms after UCO was significantly related to the patterns of the ACoAs when PCoAs were absent. The proportion of UCO ischemia in gerbils with incomplete ACoAs was significantly higher than in those with complete ACoAs. After selectively breeding five generations, the proportion of UCO ischemia increased from 40% in the F1 animals to 75% in the F5 animals. Our results suggest that variations in the CoW are genetic and demonstrate that we successfully established an ischemia-prone group of gerbils.