Long-term prognosis in patients with psoriasis
Long-term prognosis in patients with psoriasis
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DOI：
10.1111/j.1365-2133.2008.08779.x
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发表时间：
2008-09-01
影响因子：
10.3
通讯作者：
Gulliver, W.
中科院分区：
文献类型：
--
作者：
Gulliver, W.
银屑病是一种慢性、炎性、免疫介导的皮肤病，与大量合并症相关。传统的合并症包括心理/精神障碍、银屑病关节炎和炎症性肠病。越来越多的人认识到，银屑病与代谢功能障碍（包括肥胖和代谢综合征）和心血管疾病有关，从而影响发病率和死亡率。银屑病和银屑病相关合并症的潜在炎症机制涉及促炎性T辅助细胞1型细胞因子的介导。为了有效管理银屑病和相关合并症，针对皮肤和全身炎症的综合方法可能是有益的，应鼓励改善患者整体管理的策略，以减少疾病负担。本文讨论了生物制剂在这种方法中的新作用，并对现有的抗银屑病和抗银屑病治疗方法的作用进行了评价。
Psoriasis is a chronic, inflammatory, immune-mediated skin disease associated with substantial comorbidity. Traditional comorbid conditions include psychological/psychiatric disorders, psoriatic arthritis and inflammatory bowel disease. Increasingly, an association with metabolic dysfunction, including Obesity and the metabolic syndrome, and cardiovascular disease, with consequent effects Oil morbidity and mortality, has been recognized in psoriasis. The underlying inflammatory mechanisms of both psoriasis and psoriasis-associated comorbidities involve mediation by proinflammatory T-helper type 1 cytokines. For effective management of psoriasis and related comorbidides, an integrated approach targeting both cutaneous and systemic inflammation may be beneficial, and strategies to improve overall management of the patient should be encouraged to reduce the disease burden. This paper discusses the emerging role of biological agents in this approach, and offers an appreciation of the role of existing anti-psoriasis and adjunctive therapies.