Three-dimensional structures of MDR alcohol dehydrogenases
Three-dimensional structures of MDR alcohol dehydrogenases
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DOI：
10.1007/s00018-008-8589-x
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发表时间：
2008-12-01
影响因子：
8
通讯作者：
Ramaswamy, S.
中科院分区：
文献类型：
--
作者：
Eklund, H.;Ramaswamy, S.
在这篇报告中，我们描述了初步确定的乙醇脱氢酶的主要特征，马肝脏的乙醇脱氢酶，将其与人类酶结构联系起来，并回顾了最近对酶的突变体和新复合物的结构研究。我们进一步回顾了细菌醇脱氢酶的结构，以获得中链脱氢酶/还原酶醇脱氢酶的一致图像。
In this report we describe the main features of the initially determined alcohol dehydrogenase, that of horse liver, relate this to the human enzyme structures and review recent structural studies on mutants and new complexes of the enzymes. We further review the structure of a bacterial alcohol dehydrogenase to arrive at a coherent picture of medium-chain dehydrogenase/reductase alcohol dehydrogenases in general.