NETRIN and SLIT guide salivary gland migration
NETRIN and SLIT guide salivary gland migration
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DOI：
10.1016/j.ydbio.2005.04.037
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发表时间：
2005-08-01
影响因子：
2.7
通讯作者：
Beckendorf, SK
中科院分区：
文献类型：
--
作者：
Kolesnikov, T;Beckendorf, SK
定向迁移对于几乎所有器官的正确放置和功能至关重要。大多数已知的参与定向迁移的引导分子是通过对神经系统发育过程中轴突迁移的研究而确定的。在这里，我们表明至少有两种轴突引导分子，NETRIN 和 SLIT，通过它们的经典受体发挥作用，引导果蝇胚胎唾液腺。在唾液腺迁移过程中，NETRIN 充当化学吸引剂，而 SLIT 则与 NETRIN 拮抗，充当化学排斥剂。 NETRIN 和 SLIT 的 CNS 中线表达指导腺体坚定不移地平行于 CNS 移动。内脏中胚层也需要NETRIN表达，腺体在迁移过程中沿着中胚层移动。我们建议，类似于轴突引导，化学引诱剂和化学排斥剂之间的平衡对于发育中的唾液腺的正确迁移路径是必需的。 (c) 2005 Elsevier Inc. 保留所有权利。
Directed migration is pivotal for the proper placement and function of nearly all organs. The majority of known guidance molecules involved in directed migration have been identified from studies of migrating axons during nervous system development. Here, we show that at least two of these axon guidance molecules, NETRIN and SLIT, act through their canonical receptors, to guide Drosophila embryonic salivary glands. NETRIN serves as a chemo-attractant while SLIT functions antagonistically to NETRIN as a chemo-repellent during salivary gland migration. CNS midline expression of both NETRIN and SLIT directs the glands to move unswervingly parallel to the CNS. NETRIN expression is also required in the visceral mesoderm, along which the glands move during their migration. We propose that analogous to axon guidance, a balance between chemo-attractants and chemo-repellents is required for the proper migratory path of the developing salivary glands. (c) 2005 Elsevier Inc. All rights reserved.