Stem cells in the treatment of Parkinson's disease
Stem cells in the treatment of Parkinson's disease
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DOI：
10.1016/s0361-9230(01)00772-9
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发表时间：
2002-04-01
影响因子：
3.8
通讯作者：
Arenas, E
中科院分区：
文献类型：
--
作者：
Arenas, E
干细胞被认为是神经退行性疾病的候选治疗工具，因为它们能够在体内移植后产生适当的细胞类型。在这篇综述中，我总结了目前关于治疗帕金森病的两种方法的一些证据：(1)从胚胎干细胞、多能干细胞和神经祖细胞中产生多巴胺能神经元用于细胞替代疗法。(2)多能干细胞工程释放神经胶质细胞系衍生的神经营养因子，这是一种多巴胺能神经元的有效神经营养因子，在神经保护和神经再生方法中治疗帕金森病。(C) 2002爱思唯尔科学有限公司
Stem cells have been suggested as candidate therapeutic tools for neurodegenerative disorders, given their ability to give rise to the appropriate cell types after grafting in vivo. In this review I summarize some of the evidence currently available concerning two approaches for the treatment of Parkinson's disease: (1) The generation of dopaminergic neurons from embryonic stem cells, multipotent stem cells, and neuronal progenitor cells for cell replacement therapy. (2) The engineering of multipotent stem cells to release glial cell-line derived neurotrophic factor, a potent neurotrophic factor for dopaminergic neurons, in a neuroprotective and neuroregenerative approach to the treatment of Parkinson's disease. (C) 2002 Elsevier Science Inc.