Breast carcinoma with micropapillary features: Clinicopathologic study and long-term follow-up of 100 cases
Breast carcinoma with micropapillary features: Clinicopathologic study and long-term follow-up of 100 cases
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DOI：
10.1177/1066896907307047
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发表时间：
2008-04-01
影响因子：
1.2
通讯作者：
Fu, Li
中科院分区：
文献类型：
--
作者：
Chen, Ling;Fan, Yu;Fu, Li
为探讨乳腺浸润性微乳头状癌（IMPC）的临床病理特点及预后，对100例IMPC型浸润性乳腺癌进行回顾性分析。与浸润性导管癌（未另行说明）相比，组织学分级相似，IMPC癌体积较大，淋巴结转移率较高，每例累及的淋巴结较多，淋巴管浸润增加。IMPC的存在与更具攻击性的行为密切相关。IMPC组分的比例与总体肿瘤大小、组织学分级、淋巴结转移率和远处转移之间没有显著相关性，但注意到一种趋势。长期随访显示，含有IMPC成分的乳腺癌患者的5年和10年生存率较差。具有微乳头特征的乳腺癌是侵袭性更强的肿瘤，预后更差。在乳腺癌标本的外科病理学检查中，应仔细评估这种特殊结构。
To study the clinicopathologic characteristics and prognosis of invasive micropapillary carcinoma of breast (IMPC), 100 cases of invasive breast carcinoma with an IMPC component were reviewed. Compared with invasive ductal carcinoma, not otherwise specified, with similar histologic grades, carcinomas with IMPC were larger sized, had a higher lymph node metastasis rate with more nodes involved per case, and exhibited increased lymphovascular invasion. The presence of IMPC strongly correlated with the more aggressive behavior. No significant association was established between the proportion of the IMPC component and overall tumor size, histologic grade, lymph node metastasis rate, and distant metastasis, but a trend was noted. Long-term follow-up demonstrated a poorer 5-year and 10-year survival rate for patients with breast carcinoma containing an IMPC component. Breast carcinomas with micropapillary features are more aggressive tumors with a poorer prognosis. This specific structure should be carefully evaluated in the surgical pathology examination of breast carcinoma specimens.